Molecular Pharmacology and Chemical Biology | UC Davis Comprehensive Cancer Center

Molecular Pharmacology and Chemical Biology (MPCBSR)

Understanding the fate (pharmacokinetics or PK) and action (pharmacodynamics or PD) of a drug is essential for preclinical and clinical drug development as well as the practice of precision medicine. The MPCBSR helps investigators study new therapeutics for the leading causes of cancer deaths within the cancer center’s catchment area by providing comprehensive services for

  1. High-quality collection, processing, and management of clinical trial specimens and evaluation of clinical PK/PD and potential drug-drug interactions (DDI)
  2. Preclinical molecular pharmacological studies on novel agents that are translatable to the clinic, including drug metabolism and disposition (DMD), PK/PD, on-target mechanisms, biomarkers, and combination effects
  3. Chemical synthesis of new compounds and drug delivery nanomaterials for drug discovery and development

The technologies and state-of-the-art instruments available at the MPCBSR support a wide variety of molecular pharmacology and chemical biology studies. Our faculty and staff members are worldwide leaders in the fields and have the expertise to offer guidance and training for scientists on the principles and technologies used in anticancer pharmacology and chemical biology.

Key Instrumentation

Investigators working with the MPCBSR gain access to state-of-the-art equipment and instrumentation, including:

  • Four HIPA- compliant, ultra-low freezers storing up to 72,000 aliquots per freezer
  • LC-MS/MS and HPLC systems
  • Seahorse and IncuCyte live-cell analyzers
  • FPLC systems
  • Lago X in vivo animal imaging system 
  • Confocal microscope
  • Lyophilizers
  • Automated peptide synthesizers

Rates

For more details about the rate, please contact: 916-734-0905

Subsidized Rates for Cancer Center Members

Members of the cancer center receive priority access and subsidized rates for Shared Resources services. Not yet a member? Learn about the benefits and privileges of cancer center membership

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Request MPCBSR Services

We’re here to support your cancer research study. Fill out a request to use our services.

NOTE: A PPMS account is required. View our quick start guide for creating an account or set up an account.

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Contact the MPCBSR

For questions about molecular pharmacology and chemical biology or how our faculty can assist you, call the lab at 916-734-1566 or contact us.

Aiming Yu, Ph.D.

Director of the MPCBSR

Email:aimyu@ucdavis.edu

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Anthony Martinez, B.S.

Technical Director
(Clinical Specimens Collection, Processing and Management)

Email: axmartinez@ucdavis.edu

Ruiwu Liu, Ph.D.

Technical Director
(Chemical Biology Studies)

Phone: 916-734-0905
Email: ruiwu.liu@ucdmc.ucdavis.edu

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Meijuan Tu, Ph.D.

Manager
(Pharmacological Studies; DM/PK/PD)

Email: mjttu@ucdavis.edu

Helpful Links and Resources
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Notice to All NIH-Funded Investigators

CCSG and MPCBSR Acknowledgement: the authors wish to acknowledge the support of the UC Davis Comprehensive Cancer Center Molecular Pharmacology and Chemical Biology Shared Resource, supported by the National Cancer Institute of the National Institutes of Health under award number P30CA093373. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

This resource is funded by the Cancer Center Support Grant (CCSG) awarded by the National Cancer Institute (NCI P30CA093373). Publications that have utilized facility resources, services or scientific data generated by the resource should acknowledge the resource or the assistance provided by resource staff and cite the NCI CCSG. An electronic copy of the publication should also be sent to the resource directors.

National Institutes of Health (NIH) Public Access Policy