Molecular Pharmacology Services
The Molecular Pharmacology Shared Resource (MPSR) provides a wide variety of services regarding clinical and preclinical anticancer pharmacology as summarized below.
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Clinical
The MPSR works to develop and implement clinical PK/PD studies. The MPSR will coordinate and manage all specimen collection and processing for the trial principal investigator and develop new assays and conduct specimen analysis on demand to understand the PK/PD properties and potential of drug-drug interactions of tested agents.
Protocol and study development
- Specimen collection protocols and language
- Development of hypotheses and objectives for translational studies
- HIPAA compliance
- Budget development
Specimen acquisition and management
- Collection and processing of specimens
- Specimen log-in, de-identification and storage
- Provide periodic updates on specimen accrual to study PI
Specimen analysis
- Develop new assays for targeted analysis of drugs, metabolites, and specific biomarkers
- Coordinate or perform specimen analysis
- Drugs and metabolites
- Amino acids profiles
- Biomarkers
- DNA mutations
- RNA expression
- Genetic Polymorphism
- Plasma protein/nucleotide profiling
- Immunohistochemistry, multispectral imaging
- Data synthesis and analysis
Preclinical
The MPSR can design and conduct comprehensive experiments for in vitro and in vivo testing of novel agents or therapeutic combinations for discovery and proof-of-principle. Such studies can provide rationale for clinical trial development. A wide variety of molecular pharmacological approaches, and clinically-relevant cell and xenograft animal models can be utilized.
- New assays and methodologies development
- Preclinical modeling
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- Novel agent activity
- DM/PK/PD and integrated PK-PD modeling
- Drug-drug interactions
- Combination effects: synergism, addition, or antagonism
- Cancer metabolism, glycolysis, and mitochondrial functions
- Target validation
- Pharmacological mechanisms
- One-of-a-kind bioengineered RNAi agents to study cancer biology and assess new therapeutic strategies