John M. Boone, Ph.D. for UC Davis Health

John M. Boone, Ph.D.

Professor, Department of Radiology and Biomedical Engineering






Locations and Contact

Lawrence J. Ellison Ambulatory Care Center

4860 Y St.
Sacramento, CA 95817

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Additional Numbers



Clinical Interests

Dr. Boone is a medical physicist with technical expertise in breast imaging, computed tomography, and radiation dose issues in diagnostic radiology.

Research/Academic Interests

Dr. Boone is a researcher in diagnostic imaging, and has focused on issues in radiation dosimetry, breast imaging, and computed tomography. He has led an effort at UC Davis for 20 years on the development of Breast CT, and this technology is now at the threshold of clinical translation. He has also worked with collaborators to develop new x-ray tube technology which may revolutionize breast tomosynthesis imaging, and other areas in diagnostic imaging.


Medical Physics

Center/Program Affiliation

UC Davis Comprehensive Cancer Center

Undergraduate School

A.B., Biophysics, UC Berkeley, Berkeley CA 1979

Other School

M.S., Medical Physics, UC Irvine, Irvine CA 1981

Other School

Ph.D., Medical Physics, UC Irvine, Irvine CA 1985


Imaging Research, Research, Health Care Affiliates, Inc., Laguna Hills CA 1983-1985

Editor-in-Chief, Medical Physics, American Association of Physicists in Medicine, 2021

William Coolidge Gold Medal, American Association of Physicists in Medicine, 2019

The Butterfly Award, The Image Gently Consortium, 2019

Best Paper of the Year, Medical Physics Journal, American Association of Physicists in Medicine, 2012, 2015

Distinguished Investigator Award, American Academy for Radiology Research, 2013

Zhao Y, Hernandez AM, Boone JM, Molloi S. Quantification of airway dimensions using a high-resolution CT scanner: A phantom study. Med Phys. 2021 Oct;48(10):5874-5883. doi:10.1002/mp.15103. Epub 2021 Aug 18. PMID:34287955.

Wu P, Boone JM, Hernandez AM, Mahesh M, Siewerdsen JH. Theory, method, and test tools for determination of 3D MTF characteristics in cone-beam CT. Med Phys. 2021 Jun;48(6):2772-2789. doi:10.1002/mp.14820. Epub 2021 Apr 16. PMID:33660261.

Hernandez AM, Wu P, Mahesh M, Siewerdsen JH, Boone JM. Location and direction dependence in the 3D MTF for a high-resolution CT system. Med Phys. 2021 Jun;48(6):2760-2771. doi:10.1002/mp.14789. Epub 2021 Apr 15. PMID:33608927.

Caballo M, Hernandez AM, Lyu SH, Teuwen J, Mann RM, van Ginneken B, Boone JM, Sechopoulos I. Computer-aided diagnosis of masses in breast computed tomography imaging: deep learning model with combined handcrafted and convolutional radiomic features. J Med Imaging (Bellingham). 2021 Mar;8(2):024501. doi:10.1117/1.JMI.8.2.024501. Epub 2021 Mar 29. PMID:33796604.

Fedon C, Caballo M, García E, Diaz O, Boone JM, Dance DR, Sechopoulos I. Fibroglandular tissue distribution in the breast during mammography and tomosynthesis based on breast CT data: A patient-based characterization of the breast parenchyma. Med Phys. 2021 Mar;48(3):1436-1447. doi:10.1002/mp.14716. Epub 2021 Feb 3. PMID:33452822.

Becker AE, Hernandez AM, Boone JM, Schwoebel PR. A prototype Multi-X-ray-source array (MXA) for digital breast tomosynthesis. Phys Med Biol. 2020 Dec 18;65(23):235033. doi:10.1088/1361-6560/abc305. PMID:33080575.

Becker AE, Hernandez AM, Schwoebel PR, Boone JM. Cone beam CT multisource configurations: evaluating image quality, scatter, and dose using phantom imaging and Monte Carlo simulations. Phys Med Biol. 2020 Dec 18;65(23):235032. doi:10.1088/1361-6560/abc306. PMID:33080583.

Hernandez AM, Shin DW, Abbey CK, Seibert JA, Akino N, Goto T, Vaishnav JY, Boedeker KL, Boone JM. Validation of synthesized normal-resolution image data generated from high-resolution acquisitions on a commercial CT scanner. Med Phys. 2020 Oct;47(10):4775-4785. doi:10.1002/mp.14395. Epub 2020 Aug 5. PMID:32677085.

Hernandez AM, Abbey CK, Ghazi P, Burkett G, Boone JM. Effects of kV, filtration, dose, and object size on soft tissue and iodine contrast in dedicated breast CT. Med Phys. 2020 Jul;47(7):2869-2880. doi:10.1002/mp.14159. Epub 2020 Apr 27. PMID:32233091.

Siewerdsen JH, Uneri A, Hernandez AM, Burkett GW, Boone JM. Cone-beam CT dose and imaging performance evaluation with a modular, multipurpose phantom. Med Phys. 2020 Feb;47(2):467-479. doi:10.1002/mp.13952. Epub 2019 Dec 25. PMID:31808950.