Sebastian Winter, Ph.D.
Professor, Internal Medicine: Division of Infectious Diseases; Department of Medical Microbiology and Immunology
Locations and Contact
Center for Immunology and Infectious Disease
County Road 98 and Hutchison Drive
Davis, CA 95616
Patient Support Services Building
Patient Support Services Building
4150 V Street
Sacramento, CA 95817
Research/Academic Interests
The overarching theme for Dr. Winter's research group is that during episodes of intestinal inflammation, the immune response restructures the metabolic landscape of the gut. Changes in metabolite availability in turn leads to microbiota dysbiosis and, in the case of enteric pathogens, outgrowth of pathogenic bacteria. The lab uses metabolomics, transcriptomics, bacterial genetics, and host genetics to test specific hypotheses. The goal is to establish functional microbe-microbe and host-microbe interactions on a chemical biology level. This detailed, mechanistic understanding is expected to form the foundation for novel intervention strategies targeting the gut microbiota, such as rationally designed probiotics and prebiotics.
Division
Infectious Diseases
Center/Program Affiliation
Other School
Ph.D., Human Biology, Max von Pettenkofer-Institute, Ludwig Maximilian University of Munich, Munich, Germany 2010
Other School
Postdoc, Bacterial Pathogenesis, UC Davis, Davis CA 2013
Other School
M.Sc., Biochemistry, University of Bayreuth, Bayreuth, Germany 2006
Max-von-Pettenkofer Award 2023, City of Munich, Germany, City of Munich, 2023
Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases, 2018
American Cancer Society Research Scholar, 2017
ICAAC Young Investigator Award, American Society for Microbiology (ASM), 2014
Becton Dickinson Research Award, German Society for Hygiene and Microbiology (DGHM), 2011
Hughes ER, Winter MG, Alves da Silva L, Muramatsu MK, Jimenez AG, Gillis CC, Spiga L, Chanin RB, Santos RL, Zhu W, Winter SE. Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation. Elife. 2021 Jun 4;10:e58609. doi:10.7554/eLife.58609. PMID:34085924.
Chanin RB, Winter MG, Spiga L, Hughes ER, Zhu W, Taylor SJ, Arenales A, Gillis CC, Büttner L, Jimenez AG, Smoot MP, Santos RL, Winter SE. Epithelial-Derived Reactive Oxygen Species Enable AppBCX-Mediated Aerobic Respiration of Escherichia coli during Intestinal Inflammation. Cell Host Microbe. 2020 Dec 9;28(6):780-788.e5. doi:10.1016/j.chom.2020.09.005. Epub 2020 Oct 13. PMID:33053375.
Zhu W, Winter MG, Spiga L, Hughes ER, Chanin R, Mulgaonkar A, Pennington J, Maas M, Behrendt CL, Kim J, Sun X, Beiting DP, Hooper LV, Winter SE. Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis. Cell Host Microbe. 2020 Mar 11;27(3):376-388.e8. doi:10.1016/j.chom.2020.01.010. Epub 2020 Feb 18. PMID:32075741.
Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE. Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer. J Exp Med. 2019 Oct 7;216(10):2378-2393. doi:10.1084/jem.20181939. Epub 2019 Jul 29. PMID:31358565.
Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE. Precision editing of the gut microbiota ameliorates colitis. Nature. 2018 Jan 11;553(7687):208-211. doi:10.1038/nature25172. Epub 2018 Jan 3. PMID:29323293.
http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/45608688/?sort=date&direction=descending
https://profiles.ucdavis.edu/sebastian.winter
https://scholar.google.com/citations?user=8TuXhhQAAAAJ&hl=en&oi=ao