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Boryana Stamova, M.S., M.S., Ph.D.
Adjunct Professor
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Research/Academic Interests
Dr. Stamova's research focuses on deciphering how gene expression networks change in neurological and neurodegenerative diseases and neurodevelopmental disorders to ultimately pinpoint clinically useful biomarkers and determinants of pathogenesis, pathophysiology, and etiology. She and her colleagues have studied the molecular changes in ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, Alzheimer's Disease and Autism Spectrum Disorders. Another main interest of Dr. Stamova's research in how modifying factors, such as sex and age affect the molecular response in disease. In addition, Dr. Stamova is interested in personalized medicine. In particular, identifying peripheral immune system biomarkers to predict which patients would respond to a particular treatment before that treatment is administered.
Division
Neurology
Undergraduate School
Equivalent to B.S., University of Sofia (Sv. Kliment Ohridski), Sofia, Bulgaria 1996
Other School
Ph.D., Genetics, UC Davis, Davis CA 2007
Other School
M.S., Plant Biology, UC Davis, Davis CA 1999
Other School
M.S., Genetics, UC Davis, Davis CA 2001
Fellowship
Neurology, Post-Doctoral Scholar, Human Transcriptomic Studies, UC Davis, Sacramento CA 2007-2011
Amini H, Knepp B, Rodriguez F, Jickling GC, Hull H, Carmona-Mora P, Bushnell C, Ander BP, Sharp FR, Stamova B. Early peripheral blood gene expression associated with good and poor 90-day ischemic stroke outcomes. J Neuroinflammation. 2023 Jan 23;20(1):13. doi:10.1186/s12974-022-02680-y. PMID:36691064.
Knepp B, Ander BP, Jickling GC, Heather H, Yee A, Ng K, Rodriguez F, Carmona-Mora P, Amini H, Zhan X, Hakoupian M, Alomar N, Sharp F, Stamova B. Gene expression changes implicate specific peripheral immune responses to deep and lobar intracerebral hemorrhages in humans. Brain Hemorrhages. 2022;3(4):155-176. doi:10.1016/j.hest.2022.04.003.
Durocher M, Knepp B, Yee A, Jickling G, Rodriguez F, Ng K, Zhan X, Hamade F, Ferino E, Amini H, Carmona-Mora P, Hull H, Ander BP, Sharp FR, Stamova B. Molecular Correlates of Hemorrhage and Edema Volumes following Human Intracerebral Hemorrhage Implicate Inflammation, Autophagy, mRNA Splicing, and T Cell Receptor Signaling. Transl Stroke Res. 2020. In production.
Carmona-Mora P, Ander BP, Jickling GC, Dykstra-Aiello C, Zhan X, Ferino E, Hamade F, Amini H, Hull H, Sharp FR, Stamova B. Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke. J Cereb Blood Flow Metab. 2020 Sep 22:271678X20953912. doi:10.1177/0271678X20953912. Epub ahead of print. PMID:32960689.
Cheng X, Ander BP, Jickling GC, Zhan X, Hull H, Sharp FR, Stamova B. MicroRNA and their target mRNAs change expression in whole blood of patients after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2020 Apr;40(4):775-786. doi:10.1177/0271678X19839501. Epub 2019 Apr 9. PMID:30966854.
Navi BB, Mathias R, Sherman CP, Wolfe J, Kamel H, Tagawa ST, Saxena A, Ocean AJ, Iadecola C, DeAngelis LM, Elkind MSV, Hull H, Jickling GC, Sharp FR, Ander BP, Stamova B. Cancer-Related Ischemic Stroke Has a Distinct Blood mRNA Expression Profile. Stroke. 2019 Nov;50(11):3259-3264. doi:10.1161/STROKEAHA.119.026143. Epub 2019 Sep 12. PMID:31510897.
Stamova B, Ander BP, Jickling G, Hamade F, Durocher M, Zhan X, Liu DZ, Cheng X, Hull H, Yee A, Ng K, Shroff N, Sharp FR. The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes. J Cereb Blood Flow Metab. 2019 Sep;39(9):1818-1835. doi:10.1177/0271678X18769513. Epub 2018 Apr 13. PMID:29651892.
Durocher M, Ander BP, Jickling G, Hamade F, Hull H, Knepp B, Liu DZ, Zhan X, Tran A, Cheng X, Ng K, Yee A, Sharp FR, Stamova B. Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage. J Neuroinflammation. 2019 Mar 5;16(1):56. doi:10.1186/s12974-019-1433-4. PMID:30836997.
Schumann CM, Sharp FR, Ander BP, Stamova B. Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain. Mol Autism. 2017 Feb 7;8:4. doi:10.1186/s13229-017-0117-0. PMID:28184278.
Stamova B, Ander BP, Barger N, Sharp FR, Schumann CM. Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains. J Child Neurol. 2015 Dec;30(14):1930-46. doi:10.1177/0883073815602067. Epub 2015 Sep 8. PMID:26350727.