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Kristin Nicole Grimsrud, D.V.M., Ph.D.
Assistant Clinical Professor
Associate Director of Vivaria and Veterinary Care Mouse Biology Program
Specialties
Veterinarian Medicine
Pharmacology and Toxicology
Department
Locations and Contact
Additional Numbers
Physician Referrals
Philosophy of Care
Dr. Grimsrud strives to provide the highest quality of care to all animals used in research to minimize stress and discomfort to the animals and improve overall well being. Moreover, Dr. Grimsrud's clinical research aims to improve patient care and outcomes through advancing pharmacology research in understanding interpatient variability.
Clinical Interests
Clinical emphasis includes clinical care primarily for mouse and rats utilized in research including genetic modification, metabolic, surgery, vaccine and pharmacology studies. Additional interests in biosecurity and infectious disease in vivaria and laboratory animals, special populations pharmacology and translational medicine. Human clinical research focuses on studying special populations (e.g. pediatrics, burns) to improve understanding of anesthetic and analgesia medications to improve dosing regimes.
Research/Academic Interests
Research interests include pharmacology with an emphasis in pharmacogenetics, pharmacokinetics, pharmacodynamics, physiological based pharmacokinetic models and variations in special populations. Additionally, Dr. Grimsrud's research focuses on development and optimization of translational animal models.
Undergraduate School
B.S., Animal Biology, UC Davis, Davis CA 2006
Other School
Ph.D., Pharmacology and Toxicology, UC Davis, Davis CA 2012
Other School
D.V.M., UC Davis School of Veterinary Medicine, Davis CA 2011
Residency
Laboratory Animal Medicine, UC Davis, Davis CA 2013-2015
Fellowship
PostDoc Cardiothorasic Surgery, UC Davis School of Medicine, Sacramento CA 2015-2016
Top 5 Abstract, American Burn Association, 2022
Research Poster Award, UCD Human Genomics Symposium, 2019
Clinical Research Award, American Burn Association, 2018
Buck Scholarship Recipient 2002-2012,
Veterinary Scientist Training Program Fellow, Dual DVM/PhD Program 2006-2012,
Fuetsch SR, Stewart LA, Imai DM, Beckett LA, Li Y, Lloyd KCK, Grimsrud KN. Injection Reactions after Administration of Sustained-release Meloxicam to BALB/cJ, C57BL/6J, and Crl:CD1(ICR) Mice. J Am Assoc Lab Anim Sci. 2021 Jan 5. doi:10.30802/AALAS-JAALAS-20-000042. Epub ahead of print. PMID:33402233.
Grimsrud KN, Lima KM, Tran NK, Palmieri TL. Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients. J Burn Care Res. 2020 Jan 30;41(1):8-14. doi:10.1093/jbcr/irz144. PMID:31538188.
Grimsrud KN, Ivanova X, Sherwin CM, Palmieri TL, Tran NK. Identification of Cytochrome P450 Polymorphisms in Burn Patients and Impact on Fentanyl Pharmacokinetics: A Pilot Study. J Burn Care Res. 2019 Jan 1;40(1):91-96. doi:10.1093/jbcr/iry053. PMID:30371861.
Grimsrud KN, Sherwin CM, Constance JE, Tak C, Zuppa AF, Spigarelli MG, Mihalopoulos NL. Special population considerations and regulatory affairs for clinical research. Clin Res Regul Aff. 2015;32(2):47-56. doi:10.3109/10601333.2015.1001900. PMID:26401094.
VandeVoort CA, Grimsrud KN, Midic U, Mtango N, Latham KE. Transgenerational effects of binge drinking in a primate model: implications for human health. Fertil Steril. 2015 Feb;103(2):560-9. doi:10.1016/j.fertnstert.2014.10.051. Epub 2014 Dec 6. PMID:25492684.
Steele AN, Grimsrud KN, Sen S, Palmieri TL, Greenhalgh DG, Tran NK. Gap analysis of pharmacokinetics and pharmacodynamics in burn patients: a review. J Burn Care Res. 2015 May-Jun;36(3):e194-211. doi:10.1097/BCR.0000000000000120. PMID:25942648.
Sherwin CM, Stockmann C, Grimsrud K, Herd DW, Anderson BJ, Spigarelli MG. Development of an optimal sampling schedule for children receiving ketamine for short-term procedural sedation and analgesia. Paediatr Anaesth. 2015 Feb;25(2):211-6. doi:10.1111/pan.12521. Epub 2014 Sep 12. PMID:25212712.
Grimsrud KN, Ait-Oudhia S, Durbin-Johnson BP, Rocke DM, Mama KR, Rezende ML, Stanley SD, Jusko WJ. Pharmacokinetic and pharmacodynamic analysis comparing diverse effects of detomidine, medetomidine, and dexmedetomidine in the horse: a population analysis. J Vet Pharmacol Ther. 2015 Feb;38(1):24-34. doi:10.1111/jvp.12139. Epub 2014 Jul 29. PMID:25073816.
Rezende ML, Grimsrud KN, Stanley SD, Steffey EP, Mama KR. Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in the horse. J Vet Pharmacol Ther. 2015 Feb;38(1):15-23. doi:10.1111/jvp.12138. Epub 2014 Jul 28. PMID:25066475.
Grimsrud KN, Mama KR, Steffey EP, Stanley SD. Pharmacokinetics and pharmacodynamics of intravenous medetomidine in the horse. Vet Anaesth Analg. 2012 Jan;39(1):38-48. doi:10.1111/j.1467-2995.2011.00669.x. Epub 2011 Nov 22. PMID:22103480.