Peter Cala, Ph.D.

Peter M. Cala, Ph.D.





  • Human Physiology and Membrane Biology
  • Professor and Chair of


Clinical Interests

Peter M. Cala's broad research interests include membranes and transport with particular emphasis on the Na/H exchange (NHE1) and its role in cell volume and pH regulation. His current focus is on establishing structural correlates of NHE1 function based upon studies of NHE1 subtype chimeras and EPR spectroscopy. His research also includes NMR studies of the basis for hypoxia-induced cell injury using the rabbit heart as model.


Ph.D., Case Western Reserve University School of Medicine, Cleveland, Ohio, 1974

B.A., Case Western Reserve University, Cleveland, Ohio, 1970


Duke University Medical Center, Durham, North Carolina, 1974-76

Professional Memberships

American Physiological Society

Biophysiological Society

Red Blood Cell Club

Society for General Physiology

Select Recent Publications

Ortiz-Acevedo A, Rigor RR, Maldonado HM, Cala PM. Coordinated control of volume regulatory Na+/H+ and K+/H+ exchange pathways in Amphiuma red blood cells. Am J Physiol Cell Physiol. 2009 Nov 25. [Epub ahead of print]

Ortiz-Acevedo A, Rigor RR, Maldonado HM, Cala PM. Activation of Na+/H+ and K+/H+ exchange by calyculin A in Amphiuma tridactylum red blood cells: implications for the control of volume-induced ion flux activity. Am J Physiol Cell Physiol. 2008 Nov;295(5):C1316-25. Epub 2008 Sep 17.

King, S. A., E.B. Nygaard , R.R. Rigor R.R, S. F. Pedersen, and P. M. Cala. NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem. 282(27): 19716-27. Epub 2007 May 10.

Holt, M.E., S.A. King, P.M. Cala and S.E. Pedersen. Regulation of the Pleuronectes americanus Na+/H+ exchanger by osmotic shrinkage, beta-adrenergic stimuli, and inhibition of the Ser/Thre protein phosphatases. Cell. Biochem. Biophys. 45: 1-18. 2006.

Pedersen, S.F., M.E. O�Donnell, S.E. Anderson and P.M. Cala. Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain and blood. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291: R1-R25. 2006.

Anderson, S.E., D. M. Kirkland, A. Beyschau, and P.M. Cala. Acute effects of 17�-estradiol on pH, Na, and Ca and ischemia/reperfusion injury. Am J. Physiol: Cell Physiol. 288: C57-C64. 2005.

Stine F. Pedersen, Scott A. King, Robert R. Rigor, Zhenpeng Zhuang, Jaimie M. Warren, and Peter M. Cala. Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A. Am J Physiol Cell Physiol 284: C1561-C1576. 2003.

Ho HS, H. Liu, P.M. Cala and S.E. Anderson. Hypertonic perfusion inhibits intracellular Na and Ca accumulation in hypoxic myocardium. American Journal of Physiology 278: (Cell Physiol. 47) C953-C964. 2000.

McLean LA, J. Roscoe, N. K. Jorgensen, F. A. Gorin, and P. M. Cala. Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. American Journal of Physiology 278: (Cell Physiol. 47) C676-C688.