Dominik Haudenschild, Ph.D.

Dominik R. Haudenschild, Ph.D.

Specialties

Orthopaedic Research

Department

Orthopaedic Surgery

Title

  • Professor

Reviews

Research I

4635 2nd Ave., Suite 3004
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Clinic Phone: 916-734-5015
Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Clinical Interests

Dr. Haudenschild's research focus is in the interactions between the chondrocyte cytoskeleton and signal transduction events which lead to the regulation of gene expression and extracellular matrix synthesis required for the maintenance of health cartilage and the interactions between COMP and ADAMTS enzymes that create osteoarthritis biomarkers.

Research/Academic Interests

We study early responses to joint injury to learn about the pathogenesis of osteoarthritis and to identify intervention strategies. We study chondrocyte mechanobiology to understand how mechanical forces are translated into biochemical responses. We study cartilage matricellular proteins to gain insight into how cells interact with growth factors and the extracellular matrix.

We use animal models of joint injury and bone formation, explant models of osteochondral injuries, stem-cell based tissue engineering, and 3-axis bioreactors to mechanically stimulate hydrogel-embedded chondrocytes and stem cells.

We apply the knowledge to translational studies. Example: Intervene with inflammatory gene expression upon joint injury to prevent or delay OA. Example: Enhance BMP-mediated bone regeneration by presenting the growth factor in a biologically relevant context on matricellular proteins.

 

Division

Orthopaedic Research

Education

Ph.D., UC Davis, Davis CA 2003

B.A., Boston University, Boston MA 1989

Professional Memberships

American Society for Bone and Mineral Research

Editorial Review Board - Journal of Orthopaedic Research, Cartilage

Faculty of 1000 Prime (F1000)

International Cartilage Repair Society

Orthopaedic Research Society, Active Member

OsteoArthritis Research Society International, Active Member

Honors and Awards

Orthopaedic Research Society Exchange Grant, 2015

Arthritis Foundation Innovative Research Grant, 2011

Earle C. Anthony Scholarship Award, 1998

Select Recent Publications

Haudenschild DR, Eldridge A, Lein PJ, Chromy BA. High abundant protein removal from rodent blood for biomarker discovery. Biochem Biophys Res Commun. 2014 Dec 5;455(1-2):84-9. doi:10.1016/j.bbrc.2014.09.137. PMID:25445603.

Refaat M, Klineberg EO, Fong MC, Garcia TC, Leach JK, Haudenschild DR. Binding to COMP Reduces the BMP2 Dose for Spinal Fusion in a Rat Model. Spine (Phila Pa 1976). 2016 Jul 15;41(14):E829-E836. doi:10.1097/BRS.0000000000001408. PMID:26679888.

Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR, Christiansen BA. Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. Arthritis Res Ther. 2015 Feb 16;17(1):30. doi:10.1186/s13075-015-0546-0. PMID:25888819.

Klineberg E, Haudenschild DR, Snow KD, Garitty S, Christiansen BA, Acharya C, Maitra S, Gupta MC. The effect of noggin interference in a rabbit posterolateral spinal fusion model. Eur Spine J. 2014 Nov;23(11):2385-92. doi:10.1007/s00586-014-3252-8. Epub 2014 Apr 17. PMID:24740279.

Acharya C, Yik JH, Kishore A, Van Dinh V, Di Cesare PE, Haudenschild DR. Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: interaction, regulation and role in chondrogenesis. Matrix Biol. 2014 Jul;37:102-11. doi:10.1016/j.matbio.2014.06.001. Epub 2014 Jul 2. PMID:24997222.

Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Arthritis Rheumatol. 2014 Jun;66(6):1537-46. doi:10.1002/art.38378. PMID:24470357.

Hu Z, Yik JH, Cissell DD, Michelier PV, Athanasiou KA, Haudenschild DR. Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. Eur Cell Mater. 2016;30:200-9. doi:10.22203/ecm.v030a14. PMID:26859911.

Christiansen BA, Guilak F, Lockwood KA, Olson SA, Pitsillides AA, Sandell LJ, Silva MJ, van der Meulen MC, Haudenschild DR. Non-invasive mouse models of post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015 Oct;23(10):1627-38. doi:10.1016/j.joca.2015.05.009. Epub 2015 May 21. PMID:26003950.

Christiansen BA, Yik JHN, Haudenschild DR. Closed Joint ACL Disruption in Murine Model of PTA. Olson S, Guilak F. (Eds.). Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management. 2015 Jul;7:75-85.

Fukui T, Tenborg E, Yik JH, Haudenschild DR. In-vitro and in-vivo imaging of MMP activity in cartilage and joint injury. Biochem Biophys Res Commun. 2015 May 8;460(3):741-6. doi:10.1016/j.bbrc.2015.03.100. Epub 2015 Mar 26. PMID:25817731.