Integrated Cancer Biology

Integrated Cancer Biology

The Integrated Cancer Biology Program advances the understanding of the dysregulation of critical pathways that lead to cancer initiation, progression, metastasis, and recurrence with specific aims to define mechanisms of genome stability, interrogate key signaling and metabolic pathways, and identify mechanisms that impact the tumor microenvironment and tumor immunology.

The Program seeks to promote breakthrough scientific discoveries of cancer biology, which are the basis of translation from preclinical studies into the development of potential prognostic markers and therapeutic strategies. Also studied are specific processes related to cancer cells, including molecular mechanisms involved in the DNA damage response, pro-tumorigenic gene stimulation, and invasive cellular behaviors, which point to novel sites of intervention. The Program offers expertise in comparative oncology, molecular biology, biochemistry, and immunology to cancer center investigators, drives conceptual and technological innovations, and fosters interactions with other research programs to develop disease-oriented translational research.

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Membership resources for researchers

Involved in cancer research? Cancer Center membership is open to all UC Davis faculty and Lawrence Livermore National Laboratory researchers with a focused interest in cancer or related disciplines, and a commitment to contributing to the Cancer Center mission. Collaborate with like-minded investigators, gain access to resources, and contribute to the only NCI-designated Cancer Center positioned to address the cancer burden in Northern California's Central Valley.

Become a part of the collaborative research community at the UC Davis Comprehensive Cancer Center. Learn more about becoming a member and the valuable resources available to our researchers.


Integrated Cancer Biology Program Leaders

Wolf-Dietrich Heyer

Wolf-Dietrich Heyer, Ph.D.

Distinguished Professor and Chair, Department of Microbiology and Molecular Genetics

Expertise: mechanisms and regulation of maintaining genomic stability; discovered MUS81 endonuclease; first to purify full-length human BRCA2

Xinbin Chen, D.V.M., Ph.D.

Xinbin Chen, D.V.M., Ph.D.

Professor, Department of Surgical and Radiological Sciences

Expertise: mechanisms and regulation of tumor suppression; P53 family proteins

Molecular Oncology Program Research Highlights


Engrailed-1 Promotes Pancreatic Cancer Metastasis

Engrailed-1 Promotes Pancreatic Cancer Metastasis

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Engineered Bone Marrow as a Clinically Relevant ex vivo Model for Primary Bone Cancer Research and Drug Screening

Engineered Bone Marrow as a Clinically Relevant ex vivo Model for Primary Bone Cancer Research and Drug Screening

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Transcriptomic Classes of BCR-ABL1 Lymphoblastic Leukemia

Transcriptomic Classes of BCR-ABL1 Lymphoblastic Leukemia

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