In Vivo Translational Imaging
The IVTISR’s advanced imaging capabilities help investigators understand the basic mechanisms of cancer and translate their findings to the clinic. We assist in every aspect of cancer imaging studies, from design and protocol development to regulatory approvals, image acquisition and high-end image analysis. Our capabilities include imaging studies of small and large animals and humans.
Our faculty members have expertise in all aspects of in vivo translational imaging, including:
- Animal models
- Comparative pathology
- Image analysis
- Machine learning
- Medical physics
- Preclinical and clinical radiology
- Radiochemistry
Services
We support researchers in planning, executing and analyzing in vivo imaging studies. Grant writing support is available from all Shared Resources, including support letters, recommendation, statistical analysis, etc. Our imaging and translational science services include:
Access to In Vivo Imaging Technologies
Our imaging capabilities include:
- Anatomic imaging with CT and MRI
- Molecular PET, SPECT and optical imaging
- Quantitative physiologic imaging with ultrasound
- Targeted imaging probes and tracers, especially for PET imaging for animals and humans
Education and Training
The IVTISR’s faculty offer training and assistance in imaging study design, equipment operation and image analysis. We also provide training videos, classroom teaching, hands-on training and support for fellowship and trainee grant applications.
View the recharge rates for each IVTISR Center:
Let us support your cancer research study with state-of-the-art imaging capabilities. Fill out a request for IVTISR services.
NOTE: A PPMS account is required. View our quick start guide for creating an account or set up a PPMS account.
For questions about our services, please contact:
Abhijit Chaudhari, Ph.D. | Co-Director: Email
Lorenzo Nardo, M.D., Ph.D. | Co-Director: Email
Locations
Center for Molecular and Genomic Imaging (CMGI) | Genome and Biomedical Sciences Facility : 451 Health Science Dr. Davis, CA 95616
EXPLORER Molecular Imaging Center (EMIC) | UC Davis School of Medicine Department of Radiology: 4860 Y Street, Suite 3000, Sacramento, CA 95817
Please read our policies on using IVTISR and its imaging facilities:
- Operations: Daily operations within each of the three facilities are overseen by the designated operational director for that facility.
- Access: Access to each facility usually happens on a first-come, first-served basis. You may request modified scheduling from the facility director to accommodate reasonable investigator deadlines.
- Priority: Faculty members conducting small-scale studies to include pilot data for external funding proposals receive scheduling priority and additional technical assistance.
- Use of multiple facilities: When a single imaging study uses two or more facilities, technical staff from each facility will discuss coordination of effort beforehand.
Facilities and Instrumentation
The IVTISR utilizes three state-of-the-art imaging facilities for small, medium, large and human imaging:
The CMGI is a vital hub for innovation in medicine and cancer research, imaging and biomedical engineering. The center supports the development and implementation of advanced imaging protocols and innovative imaging technologies, techniques and instrumentation. CMGI also has an MOU with the Veterinary Diagnostic Imaging Service to provide large animal imaging services.
Researchers have access to our state-of-the-art radiochemistry suite and the following in vivo imaging technologies and instrumentation:
- Biomedical Cyclotron RDS 111 (Siemens)
- Biospec 7T MRI (Bruker)
- Fluorescence Imaging Cryomicrotome (Barlow Scientific)
- Focus 120 PET (Siemens)
- Gamma Counter Wallac 1470 (Perkin Elmer)
- GNEXT PET (Sofie Biosciences)
- Inveon® DPET (Siemens)
- IVIS™ Spectrum Optical Imaging (Perkin Elmer)
- MicroXCT-200 (XRadia)
- Phosphor Imager STORM 860 (Amersham Biosciences)
- Pi-PET (Brain Biosciences)
- SimPET™ 1.5T M7 MRI (Aspect Imaging)
CMGI has a memorandum of understanding with the Veterinary Diagnostic Imaging Service to provide large animal imaging services.
The EMIC is built around the first FDA-cleared total-body PET/CT scanner. The scanner features unpreceded signal collection efficiency and a spatial resolution of up to 3 millimeters. This allows researchers to obtain excellent image quality for numerous clinical and research applications.
The EMIC’s comprehensive infrastructure includes:
- Four dedicated injection rooms
- Metabolic laboratory featuring a high-performance liquid chromatography (HPLC) system and an automatic gamma counter
- Radiopharmaceutical laboratory (“hot lab”)
- Research laboratory
NOTICE TO ALL NIH-FUNDED INVESTIGATORS
CCSG Acknowledgement: research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA093373. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
IVTISR Acknowledgement: the authors wish to acknowledge the support of the UC Davis Comprehensive Cancer Center In Vivo Translational Imaging Shared Resource, supported by the National Cancer Institute of the National Institutes of Health under award number P30CA093373. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This resource is funded by the Cancer Center Support Grant (CCSG) awarded by the National Cancer Institute (NCI P30CA093373). Publications that have utilized facility resources, services or scientific data generated by the resource should acknowledge the resource or the assistance provided by resource staff and cite the NCI CCSG. An electronic copy of the publication should also be sent to the resource directors.