Mouse Biology
The Mouse Biology Shared Resource (MBSR) provides unique, sophisticated, and comprehensive resources for using mutant mice and murine cancer models in basic, applied, and preclinical translational cancer research. MBSR’s products include knockout, humanized, and transgenic mouse models for cancer research. In addition, the MBSR offers genetically-altered (e.g., CRISPR, transgenic), surgically-manipulated (e.g., PDX, CDA), and environmentally-challenged (e.g., diet, chemotherapeutic agents) services to enhance the use of existing or facilitate the develop of new mouse models for cancer research.
Mouse Models
The MBSR has over 26 years of experience creating and studying genetically modified, PDX and other types of mouse models for use in cancer studies. It has the ability to produce a wide range of allele-specific mouse models to help you achieve your research objectives. The MBSR also offers innovative technologies to phenotype mouse models that mimic human conditions.
Services
In addition to mouse models, the MBSR provides scientific and technical consultation on experimental design and planning, and also offers project and mouse colony management services for cancer researchers. The MBSR provides opportunities for training in handling of and procedures using mice and mice mouse models used for cancer research. The MBSR provides letters of support for grant applications and can assist researchers with methods and analysis of testing results for publications. The full spectrum of MBSR services includes:
Advanced Genetic Engineering and Mouse Model Services
- CRISPR genome editing, gene targeting by homologous recombination in ES cells, conditional mutagenesis and transgenesis
- Cryopreservation and recovery, assisted reproduction (IVF, ICSI) and rederivation
- Genotyping (PCR), quantitative TaqMan, transcriptome and expression analysis
- Molecular construct design, analysis, and validation
- Patient-derived xenograft (PDX) modeling, including primary tumors and frozen tissues, in immunocompromised mice and immunohumanized mice and cell-derived allografts (CDA) in immunocompetent syngeneic mice
Comprehensive Mouse Handling, Phenotyping, and Cancer Modeling Services
- Import and export of mice, germplasm and tissue
- Mouse procurement and rederivation into pathogen-free colonies
- In vivo phenotyping services, including behavior, morphology, physiology, and imaging (PET/MRI)
- SPF, high-containment barrier, and gnotobiotic mouse housing, colony management and breeding
- Gross pathology and microscopic histopathology services
NOTICE TO ALL NIH-FUNDED INVESTIGATORS
CCSG Acknowledgement: research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA093373. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
MBSR Acknowledgement: the authors wish to acknowledge the support of the UC Davis Comprehensive Cancer Center Mouse Biology Shared Resource, supported by the National Cancer Institute of the National Institutes of Health under award number P30CA093373. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This resource is funded by the Cancer Center Support Grant (CCSG) awarded by the National Cancer Institute (NCI P30CA093373). Publications that have utilized facility resources, services or scientific data generated by the resource should acknowledge the resource or the assistance provided by resource staff and cite the NCI CCSG. An electronic copy of the publication should also be sent to the resource directors.