Karen Matsukuma, M.D., Ph.D.

Karen E. Matsukuma, M.D., Ph.D.


Pathology - Gastrointestinal

Pathology - Anatomic

Pathology and Laboratory Medicine


  • Assistant Professor, Department of Pathology and Laboratory Medicine


To see if Karen E. Matsukuma is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Pathology Building

4400 V St.
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Clinic Fax: 916-734-2560
Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Research/Academic Interests

Dr. Matsukuma's research interests include pancreatic cancer, GI neuroendocrine tumors, anal dysplasia (anal intraepithelial neoplasia), Lynch syndrome, and drug-induced colitis/gastritis.


Anatomic Pathology


M.D., UC Irvine College of Medicine, Irvine CA 2007

Ph.D., Molecular Bio & Biochemistry, UC Irvine, Irvine CA 2006

B.S., UC Davis, Davis CA 1996


Anatomic Pathology, Stanford University, Stanford CA 2007-2010


GI & Liver Pathology, Johns Hopkins University, Baltimore MD 2010-2012

Surgical Pathology, Stanford University, Stanford CA 2012-2013

Board Certifications

American Board of Pathology,

Medical Board of California,

Professional Memberships

College of American Pathologists

Hans Popper Hepatopathology Society

Rodger C. Haggitt Gastrointestinal Pathology Society

United States and Canadian Academy of Pathology

Honors and Awards

Resident Teaching Award, 2016

Bright Ideas Fund Award, 2014

Select Recent Publications

Matsukuma K, Olson KA, Gui D, Gandour-Edwards R, Li Y, Beckett L. Synaptophysin-Ki67 Double Stain: A Novel Technique That Improves Interobserver Agreement in the Grading of Gastrointestinal Well-Differentiated Neuroendocrine Tumors. Mod Pathol. 2017 Jan 13. [Epub ahead of print]

Matsukuma K, Gui D, Olson KA, Tejaswi S, Clayton EF, Thai A. Osmoprep-Associated Gastritis: a Histopathologic Mimic of Iron Pill Gastritis and Mucosal Calcinosis. Am J Surg Pathol. 2016 Nov;40(11):1550-1556.

Matsukuma KE, Wei D, Sun K, Ramsamooj R, Chen M. Diagnosis and differential diagnosis of hepatic graft-versus-host disease (GVHD). J Gastrointest Oncol. 2016; 7(Suppl 1):S21-31.

Louie CY, DiMaio MA, Matsukuma KE, Coutre SE, Berry GJ, Longacre TA. Idelalisib-associated Enterocolitis: Clinicopathologic Features and Distinction from Other Enterocolitides. Am J Surg Pathol. 2015 Dec;39(12):1653-60.

de Wilde RF, Heaphy CM, Maitra A, Meeker AK, Edil BH, Wolfgang CL, Ellison TA, Schulick RD, Molenaar IQ, Valk GD, Vriens MR, Borel Rinkes IHM, Offerhaus GJA, Hruban RH, Matsukuma KE. Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Modern Pathology, 2012; 25(7):1033-9.

Matsukuma KE and Montgomery EA. Tubular carcinoids of the appendix: the CK7/CK20 immunophenotype can be a diagnostic pitfall. Journal of Clinical Pathology, 2012; 65(7):666-8.

Matsukuma KE, Mullins FM, Dietz L, Zehnder JL, Ford JM, Chun N, and Schrijver I. Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation. Human Pathology, 2010;41(8):1200-3.

Matsukuma KE, Wang Li, Moore DD, and Osborne TF. A key role for orphan nuclear receptor LRH-1 in activation of fatty acid synthase promoter by LXR. Journal of Biological Chemistry, 2007; 13;282(28):20164-71.

Matsukuma KE, Bennett MK, Huang J, Wang L, Gil G, and Osborne TF. Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase. Journal of Lipid Research, 2006; 47(12):2754-61.

Shain AH, Giacomini C, Matsukuma K, Karikari C, Bashyam M, Hidalgo M, Maitra A, and Pollack J. Convergent structural alterations define SWI/SNF chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proceedings of the National Academy of Sciences USA, 2012; 109(5):E252-9.