Combinatorial Chemistry and Chemical Biology
Co-Directors: Kit Lam, M.D., Ph.D., Ruiwu Liu, Ph.D.
Combinatorial library methods not only offer great potential for facilitating the drug discovery process but also provide powerful tools for basic research in various disciplines. These methods enable investigators to generate a large number of chemical compounds that can be used as valuable source for the discovery of drug leads, molecular imaging agents and capturing agents for molecular markers.
In the area of basic research, large collections of chemical compounds can be used to probe their effects on specific cellular function. Compounds that elicit or suppress a specific cellular response can then be identified and used as reagents to study cellular pathways involved in these cellular functions. This field of chemical genetics relies heavily on the availability of compound collections, which is difficult to find in academic laboratories.
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NOTICE TO ALL NIH-FUNDED INVESTIGATORS
CCSG Acknowledgement: research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA093373. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
MBSR Acknowledgement: the authors wish to acknowledge the support of the UC Davis Comprehensive Cancer Center Mouse Biology Shared Resource, supported by the National Cancer Institute of the National Institutes of Health under award number P30CA093373. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This resource is funded by the Cancer Center Support Grant (CCSG) awarded by the National Cancer Institute (NCI P30CA093373). Publications that have utilized facility resources, services or scientific data generated by the resource should acknowledge the resource or the assistance provided by resource staff and cite the NCI CCSG. An electronic copy of the publication should also be sent to the resource directors.