Combinatorial Chemistry and Chemical Biology
Video: Kit Lam, co-director of the Combinatorial Chemistry and Chemical Biology Shared Resource at UC Davis Comprehensive
Cancer Center, describes how combinatorial library methods for drug discovery and basic cancer research.
Combinatorial library methods not only offer great potential for facilitating the drug discovery process but also provide powerful tools for basic research in various disciplines. These methods enable investigators to generate a large number of chemical compounds that can be used as valuable source for the discovery of drug leads, molecular imaging agents and capturing agents for molecular markers.
In the area of basic research, large collections of chemical compounds can be used to probe their effects on specific cellular function. Compounds that elicit or suppress a specific cellular response can then be identified and used as reagents to study cellular pathways involved in these cellular functions. This field of chemical genetics relies heavily on the availability of compound collections, which is difficult to find in academic laboratories.
NOTICE TO ALL NIH-FUNDED INVESTIGATORS
This resource is funded by the UC Davis Comprehensive Cancer Center Support Grant (CCSG) awarded by the National Cancer Institute (NCI P30CA093373). Publications that have utilized facility resources, services or scientific data generated by the resource should acknowledge the resource or the assistance provided by resource staff and cite the NCI CCSG grant. An electronic copy of the publication should also be sent to the resource directors.