Paul Knoepfler, Ph.D.
Professor
Department
Locations and Contact
Additional Numbers
Phone
Research/Academic Interests
Paul Knoepfler is an award-winning scientist who is particularly interested in what controls stem and cancer cell biological behavior.
Known also for his popular blog – ipscell.com – and passionate stem cell advocacy, Knoepfler and his laboratory team focus on how a cell’s pluripotency control machinery goes awry during cancer.
Knoepfler is using leading-edge genomics technology to better understand why stem cells behave the way they do, and working to determine how cell behavior can be directed toward safe and effective clinical use.
Knoepfler also is an associate investigator at the Institute for Pediatric Regenerative Medicine at Shriners Hospital for Children Northern California. Along with studying the molecular programming of embryonic and neural stem cells, Knoepfler has investigated pediatric nervous system tumors and glioblastomas.
Division
Cell Biology and Human Anatomy
Center/Program Affiliation
Institute for Regenerative Cures
UC Davis Comprehensive Cancer Center
Genome Center
Institute for Pediatric Regenerative Medicine/Shriners Hospital
Undergraduate School
B.A., English Literature, Reed College, Portland OR 1989
Other School
Ph.D., Molecular Pathology, UC San Diego School of Medicine, San Diego CA 1998
National Advocacy Award, Genetics Policy Institute, 2013
CIRM New Faculty Award, 2009-2014,
March of Dimes’ Basil O'Conner Starter Scholar Award, 2008-2009,
Brain Tumor Society Award, 2007-2008,
Howard Temin Award, National Cancer Institute, 2005-2010,
Leukemia & Lymphoma Society Special Fellowship, 2002-2005,
Kim M, Knoepfler PS. Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19. Regen Med. 2021 Jun;16(6):525-533. doi:10.2217/rme-2021-0025. Epub 2021 Jun 11. PMID:34114493.
Klein RH, Knoepfler PS. Stem cell models help crack regional oncohistone codes driving childhood gliomas. Cell Stem Cell. 2021 May 6;28(5):785-787. doi:10.1016/j.stem.2021.04.013. PMID:33961758.
Chen KY, Bush K, Klein RH, et al. Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling. Commun Biol. 2020;3:363.
Knoepfler PS. Rapid change of a cohort of 570 unproven stem cell clinics in the USA over 3 years. Regen Med. 2019 Aug;14(8):735-740. doi:10.2217/rme-2019-0064. Epub 2019 Aug 28. PMID:31456478.
Knoepfler P. Gene editing: sloppy definitions mislead. Nature. 2018 Dec;564(7736):345. doi:10.1038/d41586-018-07802-2. PMID:30568213.
Knoepfler PS. Mapping and driving the stem cell ecosystem. Regen Med. 2018 Oct;13(7):845-858. doi:10.2217/rme-2018-0056. Epub 2018 Oct 5. PMID:30289055.
Klein RH, Tung PY, Somanath P, Fehling HJ, Knoepfler PS. Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer. Stem Cell Res. 2018 Aug;31:83-94. doi:10.1016/j.scr.2018.07.009. Epub 2018 Jul 19. PMID:30031967.
Knoepfler PS. Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends. Cell Stem Cell. 2018 Jul 5;23(1):18-20. doi:10.1016/j.stem.2018.06.004. Epub 2018 Jun 21. PMID:29937201.
Knoepfler PS, Turner LG. The FDA and the US direct-to-consumer marketplace for stem cell interventions: a temporal analysis. Regen Med. 2018 Jan;13(1):19-27. doi:10.2217/rme-2017-0115. Epub 2018 Jan 12. PMID:29327974.
Somanath P, Bush KM, Knoepfler PS. ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells. Stem Cells. 2018 May;36(5):671-682. doi:10.1002/stem.2776. Epub 2018 Jan 29. PMID:29327467.