Sean Michael Flynn, M.D. for UC Davis Health

Sean Michael Flynn, M.D.

Assistant Professor, Department of Surgery

To see if Sean Michael Flynn is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).



Colon and Rectal Surgery

Colorectal Surgery

Colon Cancer Prevention

Inflammatory Bowel Disease


Robotic Surgery

Minimally Invasive Surgery



Locations and Contact

UC Davis Medical Center - Cypress Building

Cypress Building- Colon and Rectal Surgery Clinic
2221 Stockton Blvd.
Sacramento, CA 95817

Get Directions

Clinic Phone: 916-734-2680

Additional Numbers

Clinic Phone


Clinic Fax


Physician Referrals

800-4-UCDAVIS (800-482-3284)

Philosophy of Care

I believe in providing compassionate, individualized care for my patients. Every patient has unique circumstances, symptoms, and conditions that affect their disease process, and their treatment needs to be tailored to best fit their personalized goals. I believe that patients truly understanding their condition and treatments is a crucial component of obtaining the optimal results we both desire. I am happy to take my time to review the critical elements, whether it is anatomy, imaging, or surgical procedures, to help my patients reach this level of understanding. 

Clinical Interests

Dr. Flynn is a colorectal surgeon specializing in conditions that affect the small intestine, colon, rectum, and anus. His practice includes a team-based approach for the care of malignant conditions of these organs, such as colon and rectal cancer, as well as benign conditions, such as inflammatory bowel disease, diverticulitis, and perianal pathology. He has undergone robotic, laparoscopic, endoscopic, and open surgical training to provide patients with the best, least invasive operation to treat their disease.

Research/Academic Interests

Dr. Flynn's research focuses on outcomes of patients undergoing surgical care for colorectal diseases. He also has a special interest in the role that our microbiome plays in the development, course, and treatment of diseases that affect the colon and rectum.


Colon and Rectal Surgery

Undergraduate School

B.A., Physics, Georgetown University, Washington DC 2009

Medical School

M.D., University of Pittsburgh, Pittsburgh PA 2014


General Surgery, UC San Diego, San Diego CA 2014-2015


General Surgery, UC San Diego, San Diego CA 2015-2021


Colorectal Surgery, University of Southern California Medical Center & Los Angeles County Medical Center, Los Angeles CA 2021-2022

Best Basic Science Paper, UC San Diego, 2019

Best Paper Award - General Surgery Forum, American Society of Colon and Rectal Surgeons, 2018

Kidwell Award of Academic Achievement in Physics Coursework, Georgetown University, 2009

Subramonian D, Phanhthilath N, Rinehardt H, Flynn S, Huo Y, Zhang J, Messer K, Mo Q, Huang S, Lesperance J, Zage PE. Regorafenib is Effective Against Neuroblastoma In Vitro and In Vivo and Inhibits the RAS/MAPK, PI3K/Akt/mTOR and Fos/Jun Pathways. Br J Cancer. 2020 Aug;123(4):568-579. doi:10.1038/s41416-020-0905-8. Epub 2020 May 27. PMID:32457362.

Flynn SM, Lesperance J, Macias A, Phanhthilath N, Paul MR, Kim JW, Tamayo P, Zage PE. The Multikinase Inhibitor RXDX-105 is Effective Against Neuroblastoma In Vitro and In Vivo. Oncotarget. 2019 Oct 29;10(59):6323-6333. doi:10.18632/oncotarget.27259. PMID:31695841.

Flynn S, Eisenstein S. Inflammatory Bowel Disease Presentation and Diagnosis. Surg Clin North Am. 2019 Dec;99(6):1051-1062. doi:10.1016/j.suc.2019.08.001. Epub 2019 Sep 11. PMID:31676047.

Flynn SM, Burchette RJ, Ghassemi M, Ratner O, Mandel D, Tomassi MJ, Klaristenfeld DD. Carnoy's Solution Fixation with Compression Significantly Increases the Number of Lymph Nodes Yielded from Colorectal Cancer Specimens. J Surg Oncol. 2019 May;119(6):766-770. doi:10.1002/jso.25372. Epub 2019 Jan 16. PMID:30650183.