Current Students
Alma Mater: UCLA
Research Interests: Cancer, genetics, drug resistance, translational medicine
About Mai Abdusamad:
Mai grew up in Portland, OR. She graduated from UCLA with a major in biochemistry and a minor in biomedical research. At UCLA, she developed an interest in cancer biology while working in the lab of Dr. Jorge Torres where she characterized the role of a novel protein in cell division and its implications in cancer. After graduation, Mai joined the Broad Institute as a research associate and Broad Cancer Genomics Scholar in the lab of Dr. Todd Golub. At the Broad, Mai worked on multiple projects that contribute to the generation of a Cancer Dependency Map—a comprehensive preclinical reference map linking genetic features of cancers to vulnerabilities to identify targets for therapeutic discovery. Outside of the lab, Mai enjoys hiking and watching foreign dramas.
Publications:
Malone C.F., Dharia N.V., Kugener G., Forman A.B., Rothberg M., Abdusamad M., Gonzalez A., Kuljanin M., Paolella B.R., Dumont N., Mancias J.D., Younger S.T., Root D.E, Golub T.R., Vazquez F., and Stegmaier K. Selective modulation of a pan-essential protein as a therapeutic strategy in cancer. Cancer Discovery. April 2021
Cohen-Sharir Y., McFarland J., Abdusamad M., Marquis C., Tang H., Ippolito M.R., Bernhard S.V., Laue K., Malaby H.L.H, Jones A., Kazachkova M., Lyons N., Nagaraja A., Bass A.J., Beroukhim R., Santaguida S., Stumpff S., Golub T.R., Storchova Z., and Ben-David U. Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition. Nature. January 2021; 590(7846): 486-491
Evans C, Olson J, Mondal B, Kandimalla P, Abbasi A, Abdusamad M … Shapiro C, Levis-Fitzgerald M, Jaworski L, Lopatto D, Clark IE, Johnson T, and Banerjee U. A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience. G3 (Bethesda). January 2021;11(1).
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M., Li YY, Spurr LF, Wu WW, Durbin AD, Wolpin BM, Piccioni F, Root DE, Boehm JS, Cherniack AD, Tsherniak A, Hong AL, Hahn WC, Stegmaier K, Golub TR, Vazquez F, and Aguirre AJ. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. December 2020;33(11):108493.
Gholkar A.A., Schmollinger S., Velasquez E.F., Lo Y.C., Cohn W., Capri J., Dharmarajan H., Deardorff W.J., Gao L.W., Abdusamad M. Whitelegge J.P., and Torres J.Z. Regulation of Iron Homeostasis Through Parkin-mediated Lactoferrin Ubiquitylation. ACS Biochemistry. August 2020; 59(32), 2916-2921.
Enache O.M., Rendo V., Abdusamad M., Lam D., Davison D., Pal S., Currimjee N., Hess J., Pantel S., Nag A., Thorner A., Root D., Doench J., Vazquez F., Beroukhim R., Golub T., and Ben-David U. Cas9 activates p53 and selects for p53-inactivating mutations. Nat Genet. May 2020; 7(52), 662–668; (Cover Article).
Please refer to my LinkedIn Profile for more information.
John Paul Aboubechara, Ph.D. – MS4
Alma Mater: UC Davis
Thesis Advisor: Kimberley McAllister, Ph.D.
MD/PhD Advisor: Kuang-Yu Jen, M.D., Ph.D.
Graduate Group: Neuroscience
About John Paul Aboubechara:
John Paul completed his Ph.D. studying the molecular mechanisms underlying synaptogenesis, and immune factors that modulate this process. He also made use of a mouse model of Maternal Immune Activation to investigate the mechanisms by which infection during pregnancy increases the susceptibility of offspring to the development of neurodevelopmental and psychiatric disorders.
He will be applying to Neurology residency this year. Long term, he plans to practice in academia, wherein he will be a neurologist, scientist, and educator, while also doing his part to advance healthcare, science, and scientific literacy. Outside of school, he enjoys spending time with his wife, family, and dog, as well as sports, music, outdoor adventures, and traveling.
Selected Publications and Posters:
Canales CP, Estes ML, Cichewicz K, Angara K, Aboubechara JP, Cameron S, Prendergast K, Su-Feher L, Zdilar I, Kreun EJ, Connolly EC, Seo JM, Goon JB, Farrelly K, Stradleigh TW, van der List D, Haapanen L, Van de Water J, Vogt D, McAllister AK, Nord AS. Sequential perturbations to mouse corticogenesis following in utero maternal immune activation. Elife. 2021
Aboubechara, JP. PhD Dissertation, “Alterations in synaptic and immune molecules in a mouse model of maternal immune activation” UC Davis Neuroscience PhD Program. 2020.
Estes ML, Prendergast K, MacMahon JA, Cameron SC, Aboubechara JP, et al. Baseline immunoreactivity before pregnancy and poly(I:C) dose combine to dictate susceptibility and resilience of offspring to maternal immune activation. Brain Behav Immun. 2020.
Cameron S, Aboubechara JP, Estes M, Gandal M, Van der List K, Farrelly K, Martinez-Horta A, Kincheloe G, MacMahon J, Haapanen L, Van de Water J, Carter CS, Schumann CM, Bauman MD, Geschwind D, and McAllister AK. Synaptic and Immune Molecule Expression in the Developing Brain in a Mouse and Non-Human Primate Model of Maternal Immune Activation. Society for Neuroscience poster session. 2018.
Prendergast K, Estes M, Farrelly K, Van der List D, Cameron S, Aboubechara JP, Martinez-Horta A, Kincheloe G, MacMahon J, Haapanen L, Bauman MD, Carter CS, Van de Water J, and McAllister AK. Baseline Immune Response and Poly(I:C) Dose Interact to Cause Behavioral and Biological Phenotypes in Offspring Following Maternal Immune Activation. Society for Neuroscience poster session. 2018.
Canales CP, Estes M, Zdilar I, Su-Feher L, Van der List D, Cameron S, Aboubechara JP, Catta-Preta R, Lim K, Stradleigh T, Haapanen L, Farrelly K, Van de Water J, McAllister AK, and Nord AS. Prenatal Gene Networks Are Altered By Maternal Immune Activation. Society for Neuroscience poster session. 2018.
Sano E, Maisnier-Patin S, Aboubechara JP, Quinones-Soto S, and Roth JR. Plasmid copy number underlies adaptive mutability in bacteria. Genetics. August 29, 2014.
Hosein R and Aboubechara JP. Prohibition of Electronic Cigarette Marketing and Advertising. California Medical Association Policy. December 7, 2014.
Wettstein Z, Aboubechara JP et al. Support for Nutrition Label Revision and FDA Review of Added Sugars American Medical Association Policy. June 9, 2014.
Recent Awards/Honors:
Ruth Werner Jacobsen Fellowship; Daniel T. O’Connor, M.D. Memorial Research Grant; Graduate Scholars Fellowship; Neuroscience Graduate Program T32 Fellowship; Medical Student Research Fellowship.
Please refer to my LinkedIn Profile for more information
Shruti graduated from the University of Michigan in 2018, where she majored in Neuroscience and Evolutionary Anthropology. At Michigan she spent 2.5 years working with Dr. Paul Jenkins and Dr. Andrew Nelson studying the underlying mechanisms of bipolar disorder in order to develop better therapeutic targets. After graduating she joined the Heit Lab at Stanford University, and her research with Dr. Jeremy Heit focused on murine models of acute ischemic stroke. She also performed brain microscopy imaging using CLARITY to study developmental cerebral vasculature patterning and vascular changes during ischemic stroke. Outside of science, Shruti enjoys traveling, cooking, and listening to podcasts.
Research Interests:
Shruti is broadly interested in neuroscience, with a focus on psychiatry. She would like to study mechanisms underlying psychiatric disease with the ultimate goal of developing better pharmacological interventions for disorders such as depression, anxiety, schizophrenia, an bipolar disorder.
Awards:
2018-2019 University of Michigan Bonderman Fellow
Publications:
Gologorsky R, Arora S, Dua A. Negative-Pressure Wound Therapy to Reduce Wound Complications after Abdominoperineal Resection. Perm J. 2020;24:19.173. doi:10.7812/TPP/19.173
Brendan Cohn-Sheehy – MS3
Alma Mater: University of California, Berkeley
Thesis Advisor: Charan Ranganath, Ph.D.
MD/PhD Advisor: Michael Rogawski, M.D., Ph.D.
Graduate Group: Neuroscience
About Brendan Cohn-Sheehy:
Brendan has long been fascinated by the human brain, how it works, and how to treat its diseases. Brendan completed a B.A. in Psychology with Honors at UC Berkeley, along with human cognitive and neuroimaging research at UC Berkeley and UCSF. Early on at UC Davis School of Medicine, Brendan was the 2015-2016 President of the Neurology Student Interest Group. He completed his Ph.D. in Neuroscience from 2016 to 2021 under the mentorship of Charan Ranganath, Ph.D., and in collaboration with a stellar, supportive team of scientists who collaborated on behavioral and brain imaging studies of complex human memories. During his Ph.D., Brendan was awarded a Floyd and Mary Schwall Medical Research Fellowship and an NIH NRSA F30 individual fellowship from the National Institute on Aging, and he also co-organized the Seminar Outreach for Minority Advocacy (SOMA) seminar series. Outside of his clinical and research obligations, Brendan tries to play a bit of music and write fiction, while struggling to train two rambunctious little dogs.
Ph.D. dissertation:
The narrative architecture of events in episodic memory and the human hippocampus
Ph.D. publications:
Cohn-Sheehy, B. I., Delarazan, A. I., Reagh, Z. M., Crivelli-Decker, J. E., Kim, K., Barnett, A. J., Zacks, J. M., & Ranganath, C. (2021). The hippocampus constructs narrative memories across distant events. Current Biology. DOI:10.1016/j.cub.2021.09.013.
Cohn-Sheehy, B. I., Delarazan, A. I., Crivelli-Decker, J. E., Reagh, Z. M., Mundada, N. S., Yonelinas, A. P., Zacks, J. M., & Ranganath, C.(2021). Narratives bridge the divide between distant events in episodic memory. Memory & Cognition. https://doi.org/10.3758/s13421-021-01178-x
Cohn-Sheehy, B.I., Ranganath, C. (2017). Time regained: how the human brain constructs memory for time. Current Opinion in Behavioral Sciences 17, 169-177. doi:10.1016/j.cobeha.2017.08.005
Selected pre-Ph.D. publications:
Ossenkoppele, R., Cohn-Sheehy, B.I., La Joie, R., Vogel, J.W., Moller, C., Lehmann, M., van Berckel, B.N.M., Seeley, W.W., Pijnenburg, Y.A., Gorno-Tempini, M.L., Kramer, J.H., Barkhof, F., Rosen, H.J., van der Flier, W.M., Jagust, W.J., Miller, B.L., Scheltens, P., Rabinovici, G.D. (2015). Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer’s disease. Human Brain Mapping, doi:10.1002/hbm.22927.
Villeneuve, S., Rabinovici, G.D., Cohn-Sheehy, B.I., Madison, C.M., Ayakta, N., Ghosh, P.M, La Joie, R., Arthur-Bentil, S.K., Vogel, J.W., Marks, S.M., Lehmann, M., Rosen, H.J., Reed, B., Olichney, J., Boxer, A.L., Miller, B.L., Borys, E., Jin, L.W., Huang, E.J., Grinberg, L.T., DeCarli, C., Seeley, W.W., Jagust, W.J. (2015). Existing Pittsburgh Compound B–positron emission tomography thresholds are too high: statistical and pathological evaluation. Brain 138(7), 2020-33.
Shimamura, A.P., Cohn-Sheehy, B.I., Pogue, Brianna L., Shimamura, T.A. (2015). How attention is driven by film edits: a multimodal experience. Psychology of Aesthetics, Creativity, and the Arts, doi:10.1037/aca0000025.
Elman, J.A., Rosner, Z.A., Cohn-Sheehy, B.I., Cerreta, A.G., Shimamura, A.P. (2013). Dynamic changes in parietal activation during encoding: implications for human learning and memory. NeuroImage 82C, 44-52.
Elman, J.A., Cohn-Sheehy, B.I., Shimamura, A.P. (2012). Dissociable parietal regions facilitate successful retrieval of recently learned and personally familiar information. Neuropsychologia 51, 573-583.
Alma Mater: UCLA (Neuroscience, French)
Thesis Advisor: Karen Moxon, Ph.D.
Graduate Group: Neuroscience
About Gregory Disse:
Greg is interested in the field of neuroengineering, hoping to implement new technologies to treat various neurological conditions. In the Neuroscience Graduate Group, he is specifically studying how spinal cord injuries change the brain and how physical therapy and brain machine interface technologies can be used to improve functional outcomes. He is an avid runner and skier.
Awards: TL1 Predoctoral Clinical Research Training Program Scholar Award (2020-2021)
Selected Abstracts and Publications:
Disse GD, Bobinski M, Lechpammer M, Steele TO, Shahlaie K. Ectopic Olfactory Neuroblastoma: A Case Report. Poster; North American Skull Base Society Annual Meeting, San Antonio, TX. February 2020.
Monzon RA, Coury JG, Disse GD, Lum ZC. Bone Cement in Total Hip and Knee Arthroplasty. JBJS Rev. 2019;7(12):e6.
Izadi A, Ondek K, Schedlbauer A, Hsu E, Disse G, Shahlaie K, Gurkoff G. Stimulation of the medial septal nucleus reduces interictal spikes, entrains oscillations, and improves object learning in epileptic rats. Poster presentation at Annual American Epilepsy Society Meeting, New Orleans, LA, December 2018.
Hunter AM, Cook IA, Tartter M, Sharma SK, Disse GD, Leuchter AF. Antidepressant treatment history and drug-placebo separation in a placebo-controlled trial in major depressive disorder. Psychopharmacology. 2015; 232(20):3833-40.
Alma Mater: B.A. in Biochemistry, University of Pennsylvania, 2016
M.S. in Chemistry, University of Pennsylvania, 2016
About Ariel Jacobi:
Originally from the East Bay, Ariel Jacobi studied the effects of D-serine on the NMDA receptor and associated proteins at the Children’s Hospital of Philadelphia. After graduating, she spent a year studying the reptilian brain in Gilles Laurent’s lab at the Max Planck Institute for Brain Research in Frankfurt, Germany. In her free time, she enjoys learning new languages and playing the piano.
Research Interests: Biochemistry of the brain, NMDA receptors, and psychiatric illnesses
Publications:
Tosches MA*, Yamawaki TM*, Naumann RK, Jacobi AA, Tushev G, and Laurent G. Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles. Science 360, 881–888 (2018).
Lin H, Jacobi AA, Anderson SA and Lynch DR. D-serine and serine racemase are associated with PSD-95 and glutamatergic synapse stability. Front Cell Neurosci, 10:34. 2016.
Catherine Le – MS4
Alma Mater: Stanford University
Thesis Advisor: William Murphy, Ph.D.
MD/PhD Advisor: David Pleasure, M.D.
Graduate Group: Immunology
About Catherine:
Catherine Le is from San Jose, CA. At UC Davis School of Medicine, she is exploring her interest in immunology and cancer biology research in the lab of Dr. William J. Murphy. Her dissertation work is focusing on the impact of human modifying factors on the biology of programmed cell death-1 (PD-1) on T cell function, activation, and maintenance.
She has completed her pre-clinical years at UC Davis School of Medicine and acted as Co-Director of Joan Viteri Memorial Clinic's Women's Clinic, where she was working on improving outreach, health education, and impact for the clinic's target population. She earned an Alpha Omega Alpha Grant to better understand the needs and priorities of the patient population at JVMC.
She graduated from Stanford University with Distinction with a Biology, B.S., and minor in English literature. In between college and medical school, she completed research as a junior specialist in the McDonald Lab at UCSF studying vascular remodeling in chronic inflammation. She enjoys trying new food, adventure biking, and reading on the latest news in immunology.
Publications:
Khuat LT, Le CT, Pai CS, Shields-Cutler RR, Holtan SG, Rashidi A, Parker SL, Knights D, Luna JI, Dunai C, Wang Z, Sturgill IR, Stoffel KM, Merleev AA, More SK, Maverakis E, Raybould HE, Chen M, Canter RJ, Monjazeb AM, Dave M, Ferrara JLM, Levine JE, Longo DL, Abedi M, Blazar BR, Murphy WJ. Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation. Sci Transl Med. 2020 Nov 25;12(571):eaay7713. doi: 10.1126/scitranslmed.aay7713. PMID: 33239390.
Le CT, Khuat LT, Caryotakis S, Wang M, Dunai C, Nguyen AV, Vick L, Stoffel KS, Blazar B, Monjazeb AM, Murphy WJ, and Soulika A. PD-1 blockade reverses obesity-mediated T-cell priming impairment. Frontiers in Immunology. 2020 October; 11:590568. doi: 10.3389/fimmu.2020.590568
Estes ML, Prendergast K, MacMahon JA, Cameron S, Aboubechara JP, Farrelly K, Sell GL, Haapanen L, Schauer JD, Horta A, Shaffer IC, Le CT, Kincheloe GN, Tan DJ, van der List D, Bauman MD, Carter CS, Van de Water J, McAllister AK. Baseline immunoreactivity before pregnancy and poly(I:C) dose combine to dictate susceptibility and resilience of offspring to maternal immune activation. Brain Behav Immun. 2020 Aug;88:619-630. doi: 10.1016/j.bbi.2020.04.061. Epub 2020 Apr 23. PMID: 32335198; PMCID: PMC7415552.
Le CT and Murphy WJ. Moving forward to address key unanswered questions on targeting PD-1/PD-L1 in cancer: limitations in preclinical models and the need to incorporate human modifying factors. Journal for ImmunoTherapy of Cancer. 2019, 7(1):291. doi: 10.1186/s40425-019-0789-4
Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, and Monjazeb AM. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nature Medicine. 2019, 25(1):141-151.
Canter, R., Le, C.T., Beerthuijzen, J.M.T., and W.J. Murphy. The Impact of Obesity as an Immune-Modifying Factor in Cancer Immunotherapy. The Journal of Leukocyte Biology. 2018, 104(3):487-497.
Martinez-Cerdeno, M., Barrilleaux, B.L., McDonough, A., Jeanelle, A., Yuen B.T.K., Somanath, P., Le, C.T., Steward, C., Horton-Sparks, K., and P.S. Knoepfler. Behavior of xeno-transplanted undifferentiated human induced pluripotent stem cells is impacted by microenvironment without evidence of tumors. Stem Cells and Development. 2017. 26(19): 1409-1423.
Le CT, Laidlaw G, Morehouse CA, Naiman B, Brohawn P, Mustelin T, Connor JR, and McDonald DM. Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-alpha in suppressing remodeling of blood vessels and lymphatics in airway inflammation. The American Journal of Pathology. 2015, 185(11):2949-68.
Raymond WW, Xu X, Nimishakavi S, Le C, McDonald DM, and Caughey GH. Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux. PLoS One. 2015; 10(5).
Awards:
2019 UC Davis Dermatology Presentation Award
2019 UC Davis Graduate Student Travel Award
2019 AAI Immunology 2019 Trainee Abstract Award
2018 Phi Kappa Phi Honor Society Nomination
2017-2018 CTSC TL1 Pre-Doctoral Research Training Award
2015 Alpha Omega Alpha Service Award (August 2015)
2015 First Lady Helen Lemieux Internship Award (June 2015-July 2015)
Selected Oral Presentations:
Le CT, Dunai C, Khuat LT, and Murphy WJ. PD-1 regulates response to bystander activation of memory CD8 T cells. AAI Immunology 2019 Conference. May 2019.
Le CT, Dunai C, Khuat LT, and Murphy WJ. PD-1 regulates response to bystander activation of memory CD8 T cells. UC Davis Dermatology Research Symposium. May 2019.
Selected Poster Presentation:
Le CT, Khuat LT, Dunai C, Soulika A, and Murphy WJ. Diet-induced obesity impairs induction of Experimental Autoimmune Encephalomyelities and is restored by PD-1 blockade. AAI Immunology 2018 Conference. May 2018.
Le CT, Khuat LT, Dunai C, Soulika A, and Murphy WJ. Diet-induced obesity impairs induction of Experimental Autoimmune Encephalomyelities and is restored by PD-1 blockade. Midwinter Conference of Immunologists. January 2018.
Le CT, Somanath P, Martinez-Cerdeno V, and Knoepfler PS. qPCR of Human ERV3 and Mouse GAPDH in mouse brains transplanted with human iPS cells. UC Davis Poster Day. March 2016.
Haber H, Conlon CE, Opsichuk ND, Salcedo MC, and Le CT. JVMC Women’s Clinic Outreach Initiative. Alpha Omega Alpha AOAle Brew Benefit. February 2016.
Ruth Lee, MS2
M.S. at UC Davis – Molecular, Cellular, & Integrative Physiology
About Ruth:
Ruth is a proud UC Davis alum and is continuing to work on her trifecta/quadfecta as an Aggie. For her PhD, she is studying the roles ion channels play in brain-related injuries/disorders (i.e., stroke, neurodegeneration) with Dr. Heike Wulff. Ruth is also working on a start-up with her team, where we aim bring a novel detector for neurodegeneration to market.
Research interests: Translational medicine, neurodegeneration, aging, inflammation, therapeutics
Publications:
Peter Deng, Julian Halmai, Ulrika Beitnere, David Lee Cameron, Michele L Martinez, Charles C Lee, Jennifer J Waldo, Krista Thongphanh, Anna Adhikari, Nycole Ashley Copping, Stela Pavlova Petkova, Ruth Diane Lee, Samantha Lock, Miranda Palomares, Henriette O'Geen, Jasmine Loraine Carter, Casiana E Gonzalez, Fiona Buchanan, Johnathon D Anderson, Jan A Nolta, Alice F. Tarantal, Jill L Silverman, David Jay Segal, Kyle David Fink. An In vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Preclinical Animal Models. Published in Frontiers in Molecular Neuroscience, section Brain Disease Mechanisms. http://journal.frontiersin.org/article/10.3389/fnmol.2021.789913/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Molecular_Neuroscience&id=789913
Pressly, B., Lee, R. D., Barnych, B., Hammock, B. D., & Wulff, H. (2021). Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the α2β3γ2 GABAA Receptor. Molecular pharmacology, 99(1), 78–91. https://doi.org/10.1124/molpharm.120.000090
Pressly, B., Lee, R. D., Singh, V., Pessah, I. N., Wulff, H. The seizure-inducing plasmic explosive RDX is a non-competitive antagonist of the A1B2Y2 GABA-A Receptor. In submission to Epilepsia.
Monica K. Lieng – MS3
Alma Mater: Juniata College
Thesis Advisors: James Marcin, M.D., M.P.H.
MD/PhD Advisor: Nick Kenyon, M.D., M.A.S.
Graduate Group: Epidemiology
About Monica:
Monica is fascinated by the interface of information technology and medicine. Her dissertation work focuses on evaluating transitions in care from generalists to specialists and studying changes in provider communication associated with telemedicine. In addition, her research interests include evaluating the impact of telemedicine on medically underserved patient populations as well as clinical data analysis and visualization. Monica is grateful for camaraderie, mentorship and opportunities at UC Davis.
Monica graduated from Juniata College with a B.S. in Biology and minors in Studio Art and Spanish. During the pre-clinical years in medical school, she served as a Co-Director of Flu Crew and Knights Landing One Health Clinic. Monica derives much joy from mentoring premedical and pre-graduate students. In her spare time, Monica enjoys exploring new places with her family, creating art, trying new fitness trends and run-walking.
For more information/expanded CV, please see Monica’s Github website.
Dissertation: "Evaluation of Telemedicine to Facilitate Care Transitions between Generalists to Specialists"
Awards: University of California Office of the President Dissertation Year Fellowship, Phi Kappa Phi Honor Society Dissertation Fellowship, TL1 Predoctoral Clinical Research Training Program Scholar Award
Selected Publications:
Monica K. Lieng, James P. Marcin, Parul Dayal, Daniel J. Tancredi, Morgan B. Swanson, Sarah C. Haynes, Patrick S. Romano, Ilana S. Sigal, Jennifer L. Rosenthal. Emergency Department Pediatric Readiness and Potentially Avoidable Transfers. The Journal of Pediatrics. 2021; ISSN 0022-3476, https://doi.org/10.1016/j.jpeds.2021.05.021.
Lieng, MK, Marcin, JP, Sigal, IS, et al. Association between emergency department pediatric readiness and transfer of noninjured children in small rural hospitals. J Rural Health. 2021; 1- 10. https://doi.org/10.1111/jrh.12566
Kim, C.H., Lieng, M.K., Rylee, T.L., Gee, K.A., Marcin, J.P., Melnikow, J.A. “School-Based Telemedicine Interventions for Asthma: A Systematic Review.” Academic Pediatrics 0, no. 0 (May 21, 2020). https://doi.org/10.1016/j.acap.2020.05.008.
Lieng, M.K., Siefkes, H.M., Rosenthal, J.L., Sauers-Ford, H.S., Mouzoon, J.L., Sigal, I.L., Dayal, P., Chen, S.T., McBeth, C.L., Dial, S.D., Dizon, G., Dannewitz, H.E., Kozycz, K., Jennings-Hill, T.L., Martinson, J.M., Huerta, J.K., Pons, E.A., Vance, N., Warnock, B.N., Marcin, J.P. Telemedicine for Interfacility Nurse Handoffs*. Pediatric Critical Care Medicine. 2019;20(9):832. https://doi.org/10.1097/PCC.0000000000002011.
Rosenthal, J.L., Lieng, M.K., Marcin, J.P., Romano, P.S. Profiling Pediatric Potentially Avoidable Transfers Using Procedure and Diagnosis Codes: Pediatric Emergency Care. March 2019:1. https://doi.org/10.1097/PEC.0000000000001777.
Alma Mater: UC Berkeley
MD/PhD Advisor: Dr. Colleen Clancy, Ph.D.
Research Interests: computational neuroscience, brain-computer interface, epilepsy, traumatic brain injury
About Ariana:
Ariana’s research background is in the area of traumatic brain injury and astrocytic inflammatory pathways associated with blood-brain barrier perturbation. She completed her thesis research under the guidance of Dr. Helen Bateup (UC Berkeley), investigating novel treatments for tuberous sclerosis complex-related cortical abnormalities. Outside of the lab, she enjoys poetry, speculative fiction, and critical theory.
Alma Mater: UCLA, 2019
Research Interests: Basic and translational immunology and autoimmunity, social determinants of health in precision medicine
About Dhiraj:
Dhiraj is a first year in the MD/PhD program and loves immunology. His primary interest is in investigating autoimmune diseases but is open to anything related to immunology, including host-pathogen immunology. Dhiraj investigated sex bias in lupus and semi-invariant T cell biology in the Autoimmunity and Tolerance Laboratory run by Dr. Ram Raj Singh at UCLA. He hopes to continue investigating autoimmune diseases at the basic and translational levels during his training. Dhiraj is also passionate about studying how the social determinants of health can be integrated into precision medicine and hopes to get involved in this work through the UC Davis Center for Precision Medicine and Data Sciences. Dhiraj is also interested in teaching and hopes to find teaching opportunities throughout his training.
Dhiraj is an avid sports fan and loves his hometown Bay Area sports teams, having grown up in San Jose. Dhiraj also loves to run, hike, camp, and try out new restaurants (when there isn’t a pandemic). He also loves reading sci-fi short stories, long form journalism, struggles through the New York Times Crossword, and will never part ways with his HBO subscription.
Publications:
Self-glycerophospholipids activate murine phospholipid-reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading.
Halder RC, Tran C, Prasad P, Wang J, Nallapothula D, Ishikawa T, Wang M, Zajonc DM, Singh RR. Eur J Immunol. 2019 Feb;49(2):242-254. doi: 10.1002/eji.201847717. Epub 2018 Dec 18.PMID: 30508304
M-LoCUS: A Scalable Intervention Enhances Growth Mindset and Internal Locus of Control in Undergraduate Students in STEM.
Nallapothula D, Lozano JB, Han S, Herrera C, Sayson HW, Levis-Fitzgerald M, Maloy J. J Microbiol Biol Educ. 2020 May 29;21(2):21.2.46. doi: 10.1128/jmbe.v21i2.1987. eCollection 2020.PMID: 32528611
Heparin and aspirin combination therapy restores T-cell phenotype in pregnant patients with antiphospholipid syndrome-related recurrent pregnancy loss.
Wang M, Zhang P, Yu S, Zhou G, Lv J, Nallapothula D, Guo C, Wang Q, Singh RR. Clin Immunol. 2019 Nov;208:108259. doi: 10.1016/j.clim.2019.108259. Epub 2019 Sep 9.PMID: 31513884 Clinical Trial.
Potential utility of anti-TNF drugs in synovial chondromatosis associated with ankylosing spondylitis.
Yu S, Wu M, Zhou G, Ishikawa T, Liang J, Nallapothula D, Singh RR, Wang Q, Wang M. Int J Rheum Dis. 2019 Nov;22(11):2073-2079. doi: 10.1111/1756-185X.13734. Epub 2019 Oct 24.PMID: 31647182 Review.
Alma Mater: CSUS, 2018
Research Interests: Neurology, Neuroscience, and Neuropharmacology
About David Perekopskiy:
David was born and raised in Sacramento, CA. He studied at California State University, Sacramento where he graduated with a degree in biochemistry. After graduating he worked at the National Institute on Drug Abuse under Dr. Eugene A. Kiyatkin in the Behavioral Neuroscience Research Branch. There David used in-vivo methods to analyze fluctuations in brain oxygen levels induced by opioids such as heroin, fentanyl, and oxycodone. Currently, David is a Co-Director at Nadezhda Clinic one of UC Davis's student-run clinics.
Publications:
Mohammad Pourhosseinzadeh – MS2
Alma Mater: B.S. at UC Davis – Biochemistry and Molecular Biology
MD/PhD Advisor: Dr. Luis Fernando Santana, Ph.D.
Research Interests: computational neuroscience, brain-computer interface, epilepsy, traumatic brain injury
About Mohammad Pourhosseinzadeh:
Mohammad was born and raised in the Greater Sacramento region and received his bachelor’s degree in Biochemistry and Molecular Biology from UC Davis. As an undergraduate he worked as a research assistant in Dr. Neil Hunter’s lab studying the molecular mechanisms of meiotic recombination in budding yeast. After graduating, Mohammad joined Dr. Mark Huising’s lab as a junior specialist, where he studied the mechanisms of pancreatic delta cell function. He enjoys baking and watching Netflix in his spare time.
Niraj Punjya - GS2
Alma Mater: B.S. 2015. Stanford University (Biology)
Thesis Advisor: Dr. David Segal, Dr. Kyle Fink
MD/PhD Advisor: Dr. Brian Jonas
Graduate Group: Biochemistry, Molecular, Cellular and Developmental Biology (BMCDB)
About Niraj Punjya:
Niraj Punjya’s research interests include using gene therapies to treat genetic disorders. At UC Davis, he works with Dr. David Segal and Dr. Kyle Fink to study 22q11.2 deletion syndrome (DiGeorge syndrome) using CRISPR activation technologies to upregulate the deleted genes characterizing the disorder. His previous research experiences involved developing geneediting technologies to study myotonic dystrophy type 1 (DM1) in the Porteus lab at Stanford University. He is fascinated with the field of genome engineering and its promise to bring these technologies into a clinical setting to treat genetic diseases.
Publications:
Pavel-Dinu M, Wiebking V, Dejene BT, Srifa W, Mantri S, Nicolas CE, Lee C, Bao G, Kildebeck EJ, Punjya N, Sindhu C, Inlay MA, Saxena N, DeRavin SS, Malech H, Roncarolo MG, Weinberg KI, Porteus MH. Gene correction for SCID-X1 in long-term hematopoietic stem cells. Nat Commun. 2019;10(1):1634. doi:10.1038/s41467-019-09614-y
Hendel A, Kildebeck EJ, Fine EJ, Clark J, Punjya N, Sebastiano V, Bao G, Porteus MH. Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing. Cell Rep. 2014;7:293-305. doi:10.1016/j.celrep.2014.02.040
Huang NF, Okogbaa J, Lee JC, Jha A, Zaitseva TS, Paukshto MV, Sun JS2, Punjya N, Fuller GG, Cooke JP. The modulation of endothelial cell morphology, function, and survival using anisotropic nanofibrillar collagen scaffolds. Biomaterials. 2013;34(16):4038-4047. doi:10.1016/j.biomaterials.2013.02.036
Anna Sadovnikova, MS3, PhD, IBCLC, MPH, MA, is a mammary gland biologist and clinical lactation specialist.
Low milk production is one of the main reasons mothers stop breastfeeding. Anna completed her PhD training in the Hovey Lab because she wanted to build upon the research skills she gained in public health and social entrepreneurship to become a leading physician-scientist in the lactation field. Through her doctoral work, Anna developed research expertise in comparative mammary gland biology, specifically in the genetic regulation of milk production.
During her dual-masters, Anna focused on international human donor milk banking policies and practices. Between 2014 and 2021, Anna was the CEO of LiquidGoldConcept, a company that specialized in simulation-based training of healthcare professionals in clinical lactation and maternal-child care. Anna maintains an active clinical practice where she provides advanced lactation care to pregnant and postpartum patients.
Awards and Honorable Mention
UC Davis Keller Pathways Fellow, 2015-2016
Publications and selected abstracts
Chuisano SA, Anderson OS, Weirauch K, Roper R, Phillips J, McCabe C, Sadovnikova, A. An Application of Kane’s Validity Framework to Evaluate Formative and Summative Assessment Instruments for Telesimulations in Clinical Lactation. Simul Healthc 2022. https://doi.org/10.1097/SIH.0000000000000653.
Anderson OS, Phillips J, Weirauch K, Chuisano SA, Sadovnikova A. Development of Team Behavior Skills and Clinical Lactation Competence Among Medical Students Engaging in Telesimulations with Standardized Patients. Breastfeed Med 2022. https://doi.org/10.1089/bfm.2021.0229.
Grabowski, A, Chuisano, SA, Strock, K, Zielinski, R, Anderson O, and Sadovnikova, A. A Pilot Study to Evaluate the Effect of Classroom-Based High-Fidelity Simulation on Midwifery Students’ Self-Efficacy in Clinical Lactation and Perceived Translation of Skills to the Care of the Breastfeeding Mother-Infant Dyad. Midwifery, June 30, 2021, 103078. https://doi.org/10.1016/j.midw.2021.103078.
Sadovnikova A, Garcia SC, Hovey RC. A comparative review of the extrinsic and intrinsic factors regulating lactose synthesis. Journal of Mammary Gland Biology and Neoplasia 2021.
Sadovnikova, A, Garcia, SC, Hovey, RC. A comparative review of the cell biology, biochemistry, and genetics of lactose synthesis. Journal of Mammary Gland Biology and Neoplasia 2021.
Anderson, O, Weirach, K, Roper, R, Phillips, J, Chuisano, A, McCabe, C, Sadovnikova, A. The Efficacy of Hybrid Telesimulation with Standardized Patients in Teaching Medical Students Clinical Lactation Skills: A Pilot Study. Breastfeed Med 2021. https://doi.org/10.1089/bfm.2020.0253.
Anderson OS, McCabe CF, Chuisano SA, Wicoff E, Grabowski A, Sadovnikova A. Virtual Experiential Learning: A Description of an Internship Framework That Engages Students to Build Public Health Competencies. Pedagogy in Health Promotion 2020:2373379920977537. https://doi.org/10.1177/2373379920977537.
Grabowski A, Anderson OS, Zielinski R, Scott M, Hammer L, Bassil M, Chuisano SA, Sadovnikova, A. Midwifery students better approximate their self-efficacy in clinical lactation after reflecting in and on their performance in the LactSim OSCE. Advances in Simulation 2020;5:28. https://doi.org/10.1186/s41077-020-00143-z.
Sadovnikova A, Chuisano SA, Ma K, Grabowski A, Stanley KP, Mitchell KB, Eglash, A, Plott, J, Zielinski, R, Anderson, A. Development and evaluation of a high-fidelity lactation simulation model for health professional breastfeeding education. International Breastfeeding Journal 2020;15:8. https://doi.org/10.1186/s13006-020-0254-5.
Sadovnikova A, Wysolmerski JJ, Hovey RC. Chapter 14 - The Onset and Maintenance of Human Lactation and its Endocrine Regulation. In: Kovacs CS, Deal CL, editors. Maternal-Fetal and Neonatal Endocrinology, Academic Press; 2020, p. 189–205. https://doi.org/10.1016/B978-0-12-814823-5.00014-3.
Sidhu S, Ma K, Sadovnikova A. Features and Educational Content Related to Milk Production in Breastfeeding Apps: Content Analysis Informed by Social Cognitive Theory. JMIR Pediatrics and Parenting 2019;2:e12364. https://doi.org/10.2196/12364.
Ecoiffier T, Sadovnikova A, Yuen D, Chen L. Conjunctival Lymphatic Response to Corneal Inflammation in Mice. J Ophthalmol 2012;2012. https://doi.org/10.1155/2012/953187.
Yuen D, Leu R, Sadovnikova A, Chen L. Increased Lymphangiogenesis and Hemangiogenesis in Infant Cornea. Lymphat Res Biol 2011;9:109–14. https://doi.org/10.1089/lrb.2011.0005.
Selected Abstracts
Sadovnikova, A, Sommers, J, Oberhelman, S. Preliminary results from a survey of the pharmacologic, herbal, and nutritional galactagogue prescribing practices of physicians in the United States and Canada. Academy of Breastfeeding Medicine. November 2020. (Abstract)
Sadovnikova, A, Mathews, AT, Garcia, S, Trott, J, Hovey, RC. Effect of a single high dose of dexamethasone on milk production, composition, and mammary gland gene expression. American Dairy Science Association. Cincinnati, Ohio. June 23-26, 2019. (Abstract).
Sadovnikova, A. Chuisano, S., Ma, K., McQueer, B., Larson, S., Watkins, M., Anderson, O. Breastfeeding Training of Hospital Staff in the United States: A Nationwide Survey of “Step 2” Implementation in Baby-Friendly Hospitals. Abstracts from The Academy of Breastfeeding Medicine 23rd Annual International Meeting San Francisco, California November 14–17, 2018. Breastfeeding Medicine 2018;13:S-1. https://doi.org/10.1089/bfm.2018.29106.abstracts.
Sadovnikova A, Zielinski R, Anderson O, Hammer L, Scott M, Ma K, et al. A Mixed-Methods, Innovative Pilot Program to Assess the Impact of Teaching Midwifery Students Hands-On Breastfeeding Management Using a Lactation Simulation Model. Journal of Obstetric, Gynecologic & Neonatal Nursing 2018;47:S6. https://doi.org/10.1016/j.jogn.2018.04.013.
Anderson OS, Connolly M, Sadovnikova A. Professional portfolio development in a nutrition capstone course to guide student self-regulated learning and curriculum assessment. The FASEB Journal 2017;31:975.3-975.3. https://doi.org/10.1096/fasebj.31.1_supplement.975.3.
Annica Stull-Lane – GS4
Alma Mater: Oberlin College
Thesis Advisor: Renee Tsolis
MD/PhD Advisor: Jay V. Solnick
Graduate Group: Integrative Pathobiology
About Annica Stull-Lane:
Annica is fascinated by our microbial world, from the commensal microbiome to pathogens of infectious disease. Microbiological laboratory research became her passion over time through work and research during her liberal arts education at Oberlin College, via a postbaccalaureate APHL/CDC Emerging Infectious Diseases Laboratory Fellowship, and at a startup biotech position. Annica is excited to train at UC Davis, furthering this work that will guide her towards her career goal: to serve as a physician-scientist who heads an academic lab; teaches and mentors; and collaborates with scientists, physicians and patients. She is interested in studying infectious diseases of global and public health importance, elucidating molecular mechanisms of disease, and addressing complex health problems through the One Health approach. In the clinic, Annica values working with underserved populations, improving health outcomes through teamwork and dedication. Ultimately, she looks forward to collaborating with creative thinkers to alleviate health disparities through discovery. Apart from her clinical and research interests, Annica enjoys hiking, cooking, and singing.
Publications:
Stull-Lane A, Lokken-Toyli KL, Diaz-Ochoa VE, Walker GT, Cevallos SA, Winter ALN, et al. Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice. PLoS Negl Trop Dis. 2020;14(10).
Lokken KL, Stull-Lane A, Poels K, Tsolis RM. Malaria Parasite-Mediated Alteration of Macrophage Function and Increased Iron Availability Predispose to Disseminated Nontyphoidal Salmonella Infection. Infect Immun. 2018;86(9).
Delisle J, Mendell NL, Stull-Lane A, Bloch KC, Bouyer DH, Moncayo AC. Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee. Am J Trop Med Hyg. 2016;94(6):1212-7.
Baumblatt JA, Dunn JR, Schaffner W, Moncayo AC, Stull-Lane A, Jones TF. An outbreak of bed bug infestation in an office building. J Environ Health. 2014;76(8):16-8.
Patterson JL, Stull-Lane A, Girerd PH, Jefferson KK. Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis-associated anaerobes. Microbiology. 2010;156(Pt 2):392-9.
Alma Mater: UC San Diego
About Kelly Weldon:
Selected Pre-PhD Publications:
Burnett LA, Hochstedler BR, Weldon KC, Wolfe AJ, Brubaker L. Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women. Neurourology and Urodynamics. 2021; 40: 1479- 1489. https://doi.org/10.1002/nau.24707
Taylor BC, Weldon KC, Ellis RJ, Franklin D, Groth T, Gentry EC, Tripathi A, McDonald D, Humphrey G, Bryant M, Toronczak J, Schwartz T, Oliveira MF, Heaton R, Grant I, Gianella S, Letendre S, Swafford A, Dorrestein PC, Knight R. 2020. Depression in individuals coinfected with HIV and HCV is associated with systematic differences in the gut microbiome and metabolome. mSystems 5:e00465-20. https:// doi.org/10.1128/mSystems.00465-20.
Taylor BC*, Weldon KC*, Ellis RJ, Franklin D, McDonald D, Humphrey G, Bryant M, Toronczak J, Schwartz T, Iudicello J, Heaton R, Grant I, Gianella S, Letendre S, Swafford A, Dorrestein PC, Knight R. 2020. Reduced independence in daily living is associated with the gut microbiome in people with HIV and HCV. mSystems 5:e00528-20. https://doi.org/10 .1128/mSystems.00528-20.
Vargas F*, Weldon KC*, Sikora N, Wang M, Zhang Z, Gentry EC, Panitchpakdi MW, Caraballo-Rodríguez AM, Dorrestein PC, Jarmusch AK. Protocol for community-created public MS/MS reference spectra within the Global Natural Products Social Molecular Networking infrastructure. Rapid Commun Mass Spectrom. 2020 May 30;34(10):e8725. doi: 10.1002/rcm.8725. PMID: 31930757.
Wang M, Jarmusch AK, Vargas F, Aksenov AA, Gauglitz JM, Weldon KC, Petras D, et al. Mass spectrometry searches using MASST. Nat Biotechnol. 2020 Jan;38(1):23-26. doi: 10.1038/s41587-019-0375-9. PMID: 31894142; PMCID: PMC7236533.
Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, et al. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 Mar;579(7797):123-129. doi: 10.1038/s41586-020-2047-9. Epub 2020 Feb 26. PMID: 32103176; PMCID: PMC7252668.
Fang X, Vázquez-Baeza Y, Elijah E, Vargas F, Ackermann G, Humphrey G, Lau R, Weldon KC, et al. Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity, Inflammatory Bowel Diseases, Volume 27, Issue 5, May 2021, Pages 603–616, https://doi.org/10.1093/ibd/izaa262
Lillian Zhang – MS3
Alma Mater: UCLA
Thesis Advisor: Andreas Baumler
MD/PhD Advisor: Richard Harper
Graduate Group: Immunology
2022 Matched at Cornell, IM Medical Research Track
Publications:
Rivera-Chavez F, Lopez CA, Zhang LF, Garcia-Pastor L, Chavez-Arroyo A, Lokken KL, Tsolis RM, Winter SE, Baumler AJ. Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion. MBio. 2016 Jul 19:7(4): 443-54.
Rivera-Chavez F, Zhang LF, Faber F, Lopez CA, Byndloss MX, Olsan EE, Xu G, Velazquez EM, Lebrilla CB, Winter SE, Baumler AJ. Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella. Cell Host Microbe. 2016 Apr 13;19(4):443-54.
Leung TH, Zhang LF, Wang J, Ning S, Knox SJ, Kim SK. Topical hypochlorite ameliorates NF-kB-mediated skin diseases in mice. J Clin Invest. 2013 Dec; 123(12):5361-70.
Leung TH , Zhang LF, Wang J, Ning S, Knox SJ, Kim SK.Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice. J Clin Invest. 2013.
Chan CK, Lindau P, Jiang W, Chen JY, Zhang LF, Chen CC, Seita J, Sahoo D, Kim JB, Lee A, Park S, Nag D, Gong Y, Kulkarni S, Luppen CA, Theologis AA, Wan DC, DeBoer A, Seo EY, Vincent-Tompkins JD, Loh K, Walmsley GG, Kraft DL, Wu JC, Longaker MT, Weissman IL. Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells. Proc Natl Acad Sci U S A. 2013.