The goal of In Vivo Modeling is to apply next-generation genome manipulation technologies and targeted phenotyping strategies to generate reliable mouse models in support of biomedical research and precision medicine.  This is accomplished by recapitulating patient-specific genetic variants using gene targeting and editing (e.g., CRISPR/Cas9) in mice that are analyzed using disease-related customized tests and procedures. Comprehensive, cross-species and systems-based informatics analysis of data, images, and other information generated from testing mice can then be used to draw clinically-informative conclusions for diagnosis, treatment recommendations, and prevention strategies. Combining these molecular, analytical, and informatics tools can accelerate improvements in individual health management and surgical outcomes. In Vivo Modeling is essential for the evolution of precision medicine as a new paradigm in clinical decision-making and health care.

As a global leader in precision animal modeling, we seek to catalyze the implementation of personalized medicine. We continue to pursue new and innovative technologies, develop novel resources, and embrace opportunities to collaborate with like-minded partners committed to transforming biomedical research.

After nearly two decades, we continue to be an innovator of new approaches and next generation strategies to generate, phenotype, and analyze genetically-altered mouse models that recapitulate the clinical consequences of disease in individual patients.

Today, we are at the forefront of design and derivation of genome-edited mice for precision disease modeling in support of personalized medicine. With a dedicated and motivated team of scientists, technical staff, and students, we utilize advanced technologies in embryo manipulation, genetic engineering, and phenotyping testing and analysis to assist clinician scientists and translational science researchers use mouse models to study functional genomics in health and disease.