
Research Faculty
Project Scientist
Biomedical Engineering
Ophthalmology
Neuroscience
Opto-electronics Instrumentation Engineering
Dr. Meleppat's research interests include Biomedical Engineering, Biomedical Instrumentation, Optical Imaging, Biophotonics, Ophthalmic Imaging, Opthalmology, Visual Neuroscience, Optical coherence tomography (OCT), OCT Angiography, Adaptive Optics, Multicolor Fluorescence Imaging, Hyperspectral Imaging, Machine Learning & Artificial Intelligence, and Confocal fluorescence Imaging.
Optometry
B.Tech., Electronics & Communication Engineering, University of Calicut, India 2006
Ph.D., Mechanical Engineering (Biomedical Optical Imaging), Nanyang Technological University Singapore, Singapore 2017
M.Tech., Optoelectronics & Optical Communication, University of Kerala, India 2011
Postdoctoral Scholar, UC Davis, Davis CA 2017-2022
Served as a Juror of the 36th Annual California State University Student Research Competition (Engineering and Computer science) hosted by San Francisco State University on 29th and 30th, 2022
Received Nanyang Technological University Research Student Scholarship (NTU-RSS) for pursuing Ph.D. program (2012-2016), 2016
Received post-graduate scholarships (India Government (MHRD) scholarship) for pursuing Master degree (M.Tech) program.(2009-2011), 2011
Qualified Graduate Aptitude Test in Engineering (GATE-India) with a 92.47 percentile score, 2009
Meleppat R, Valente D, Lee S, Jonnal R, Doble N, Zawadzki R. On-axis full-field swept-source optical coherence tomography for murine retinal imaging, Optics Letters, 49(16), 2024.
R. K. Meleppat, C. R. Fortenbach, Y. Jian et al., In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography. Translational Vision Science & Technology. 11(8), 11-11 (2022).
Chung SH, Sin TN, Dang B, Ngo T, Lo T, Lent-Schochet D, Meleppat RK, Zawadzki RJ, Yiu G. CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization. Mol Ther Nucleic Acids. 2022 Apr 27;28:613-622. doi:10.1016/j.omtn.2022.04.015. PMID:35614998.
Pijewska E, Zhang P, Meina M, Meleppat RK, Szkulmowski M, Zawadzki RJ. Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system. Biomed Opt Express. 2021 Nov 30;12(12):7849-7871. doi:10.1364/BOE.439900. PMID:35003871.
Meleppat RK, Ronning KE, Karlen SJ, Burns ME, Pugh EN Jr, Zawadzki RJ. In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium. Sci Rep. 2021 Aug 10;11(1):16252. doi:10.1038/s41598-021-95320-z. PMID:34376700.
Ramos-Soto O, Rodríguez-Esparza E, Balderas-Mata SE, Oliva D, Hassanien AE, Meleppat RK, Zawadzki RJ. An efficient retinal blood vessel segmentation in eye fundus images by using optimized top-hat and homomorphic filtering. Comput Methods Programs Biomed. 2021 Apr;201:105949. doi:10.1016/j.cmpb.2021.105949. Epub 2021 Jan 27. PMID:33567382.
Meleppat RK, Ronning KE, Karlen SJ, Kothandath KK, Burns ME, Pugh EN Jr, Zawadzki RJ. In Situ Morphologic and Spectral Characterization of Retinal Pigment Epithelium Organelles in Mice Using Multicolor Confocal Fluorescence Imaging. Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):1. doi:10.1167/iovs.61.13.1. PMID:33137194.
Meleppat RK, Zhang P, Ju MJ, Manna SK, Jian Y, Pugh EN, Zawadzki RJ. Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium. J Biomed Opt. 2019 Jun;24(6):1-10. doi:10.1117/1.JBO.24.6.066011. PMID:31254332.
Zhang P, Miller EB, Manna SK, Meleppat RK, Pugh EN Jr, Zawadzki RJ. Temporal speckle-averaging of optical coherence tomography volumes for in-vivo cellular resolution neuronal and vascular retinal imaging. Neurophotonics. 2019 Oct;6(4):041105. doi:10.1117/1.NPh.6.4.041105. Epub 2019 Sep 4. PMID:31528657.
Zhang P, Manna SK, Miller EB, Jian Y, Meleppat RK, Sarunic MV, Pugh EN Jr, Zawadzki RJ. Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography. Biomed Opt Express. 2019 Jan 15;10(2):552-570. doi:10.1364/BOE.10.000552. PMID:30800499.