Barbara L. Shacklett, Ph.D.
Professor, Department of Medical Microbiology and Immunology
Specialties
Cellular and Mucosal Immunology
Infectious Diseases
Human Immunodeficiency Virus (HIV)
Locations and Contact
Research/Academic Interests
Our main topic of research is chronic HIV infection, with an emphasis on the body's immune response to HIV in the gastrointestinal and reproductive tracts as well as the central nervous system.
We are also very interested in HIV prevention strategies, including vaccines and microbicides. Work in the laboratory is funded by grants from the National Institutes of Health (NIH).
Our major areas of study can be summarized as:
1) Cellular Immunology: T-cell biology, innate-like T-cell subsets
2) Mucosal Immunology: Adaptive immunity in the gastrointestinal and reproductive tracts
3) Infectious Diseases: HIV and other sexually transmitted diseases. Emerging viruses.
4) Human Immunodeficiency Virus (HIV): Pathogenesis, vaccine development, prevention strategies.
Division
Medical Microbiology and Immunology
Infectious Diseases
Center/Program Affiliation
Undergraduate School
B.S., Microbiology, Rutgers University, New Brunswick NJ 1985
Other School
Ph.D., Microbiology, UC Davis, Davis CA 1994
Fellowship
Cellular and Mucosal Immunology, Aaron Diamond AIDS Research Center/Rockefeller University, New York NY 1997-2000
Fellowship
Molecular Virology, Institut Cochin, Paris, France 1994-1997
https://www.ncbi.nlm.nih.gov/myncbi/barbara.shacklett.1/bibliography/public/
Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ. Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response. J Infect Dis. 2021 Nov 16;224(9):1593-1598. doi:10.1093/infdis/jiab121. PMID:33693750.
Munusamy Ponnan S, Thiruvengadam K, Tellapragada C, Ambikan AT, Narayanan A, Kathirvel S, Mathayan M, Shankar J, Rajaraman A, Afshan Amanulla M, Dinesha TR, Poongulali S, Saravanan S, Murugavel KG, Swaminathan S, Velu V, Shacklett B, Neogi U, Hanna LE. Deciphering the Role of Mucosal Immune Responses and the Cervicovaginal Microbiome in Resistance to HIV Infection in HIV-Exposed Seronegative (HESN) Women. Microbiol Spectr. 2021 Oct 31;9(2):e0047021. doi:10.1128/Spectrum.00470-21. Epub 2021 Oct 27. PMID:34704803.
SenGupta D, Brinson C, DeJesus E, Mills A, Shalit P, Guo S, Cai Y, Wallin JJ, Zhang L, Humeniuk R, Begley R, Geleziunas R, Mellors J, Wrin T, Jones N, Milush J, Ferre AL, Shacklett BL, Laird GM, Moldt B, Vendrame E, Brainard DM, Ramgopal M, Deeks SG. The TLR7 agonist vesatolimod induced a modest delay in viral rebound in HIV controllers after cessation of antiretroviral therapy. Sci Transl Med. 2021 Jun 23;13(599). doi:10.1126/scitranslmed.abg3071. PMID:34162752.
Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW. Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression. PLoS One. 2021;16(5):e0250987. doi:10.1371/journal.pone.0250987. eCollection 2021. PMID:33983973.
O'Neil TR, Hu K, Truong NR, Arshad S, Shacklett BL, Cunningham AL, Nasr N. The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection. Viruses. 2021 Feb 25;13(3). doi:10.3390/v13030359. PMID:33668777.
Seidman D, Cavrois M, Hilton JF, Roan NR, Averbach S, Takeda M, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. Reproductive tract immune cells from pregnant women or those using depot medroxyprogesterone acetate show no excess susceptibility to HIV-1: Results of an ex vivo fusion assay. Contraception. 2021 Jan;103(1):44-47. doi:10.1016/j.contraception.2020.09.003. Epub 2020 Sep 30. PMID:33007299.
Chang WLW, Deere JD, Kieu HT, Castillo LD, Machmach K, Shen X, Tomaras GD, Shacklett BL, Barry PA, Hartigan-O'Connor DJ, Sparger EE. RhCMV serostatus and vaccine adjuvant impact immunogenicity of RhCMV/SIV vaccines. Sci Rep. 2020 Aug 20;10(1):14056. doi:10.1038/s41598-020-71075-x. PMID:32820216.
Elmes J, Silhol R, Hess KL, Gedge LM, Nordsletten A, Staunton R, Anton P, Shacklett B, McGowan I, Dang Q, Adimora AA, Dimitrov DT, Aral S, Handanagic S, Paz-Bailey G, Boily MC. Receptive anal sex contributes substantially to heterosexually acquired HIV infections among at-risk women in twenty US cities: Results from a modelling analysis. Am J Reprod Immunol. 2020 Aug;84(2):e13263. doi:10.1111/aji.13263. Epub 2020 Jun 9. PMID:32384198.
Shanmugasundaram U, Critchfield JW, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL. Parallel studies of mucosal immunity in the reproductive and gastrointestinal mucosa of HIV-infected women. Am J Reprod Immunol. 2020 Jul;84(1):e13246. doi:10.1111/aji.13246. Epub 2020 May 8. PMID:32301548.