Pituitary and Hypothalamic Disorders | Endocrinology

Endocrinology and Diabetes

Pituitary and Hypothalamic Disorders

At UC Davis Health, we focus on all types of pituitary and hypothalamic disorders. We provide highly skilled diagnosis, treatment and care to help you feel better.

Medically reviewed by Dana Sheely, M.D. on March 08, 2024.

Health care provider’s hands holding patient's hands on a desk.

Experts Ready to Treat Pituitary and Hypothalamic Disorders

At the UC Davis Health Division of Endocrinology, our renowned providers specializing in hormones (endocrinologists) diagnose and treat all types of pituitary and hypothalamic disorders. We offer knowledgeable and compassionate care to help our patients lead full lives.

On this page
family_history

What Are Pituitary and Hypothalamic Disorders?

Your pituitary is a pea-sized gland at the base (underside) of your brain. It makes several hormones that coordinate functions in your body. It also controls the functions of other glands in your endocrine system. The hypothalamus controls the pituitary and is a part of your brain that sits just above it.

Your pituitary helps to manage:

  • Breast milk production (lactation)
  • Growth and metabolism
  • Production of estrogen, testosterone and sperm, as well as egg development and ovulation
  • Response to stress
  • Your body’s balance of water and sodium
  • Labor and childbirth

Pituitary and hypothalamic disorders happen when your glands make too much or not enough hormones.

Common Types of Pituitary and Hypothalamic Disorders

Acromegaly

Parts of your body, such as your bones, cartilage and tissues, may increase in size due to overproduction of growth hormone. This condition is called gigantism when it occurs in children.

Cushing’s Disease

This disease is caused by overproduction of the adrenocorticotropic hormone (ACTH) which results in excess cortisol from the adrenal glands. It may cause rapid weight gain in your abdomen, chest, back of your neck and face, and an increase in blood sugar and blood pressure.

Arginine-Vasopressin Deficiency (Formally Known as Diabetes Insipidus)

This condition causes increased thirst and urination. Arginine-Vasopressin Deficiency occurs when your pituitary releases too little antidiuretic hormone (ADH).

Empty Sella Syndrome (ESS)

ESS is a radiographic diagnosis in which the pituitary gland appears flattened or shrunk due to issues with the skull around it. It doesn’t always cause symptoms but may lead to hormonal imbalances and headaches.

Growth Hormone Deficiency

This condition can cause metabolic issues in adults and lack of growth or delayed puberty in children. It occurs when your pituitary releases too little growth hormone (GH).

Hyperprolactinemia and Prolactinoma

These conditions, caused by high levels of the prolactin hormone, result in infertility and a milky nipple discharge (galactorrhea).

Pituitary Adenomas

Most of these tumors are noncancerous (benign) but may cause vision problems if they press against your optic nerve.

Sheehan’s Syndrome

Damage to your pituitary gland during childbirth due to extreme blood loss causes Sheehan’s syndrome. This condition can result in many hormone deficiencies and symptoms.

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

SIADH causes water retention and low sodium levels in your blood. It occurs when your hypothalamus makes too much ADH.

settings_accessibility

Symptoms of Pituitary and Hypothalamic Disorders

Pituitary and hypothalamic disorders symptoms vary based on whether benign tumors or other hormone imbalances cause them.

Common Symptoms of Pituitary Hormone Imbalances

These symptoms could be signs of pituitary hormone imbalances:

  • Anxiety or depression
  • Growth problems
  • Unexplained weight changes
  • Infertility or sexual concerns
  • Irregular periods

Common Symptoms of Benign Pituitary Tumors

These additional symptoms could be signs of pituitary tumors: 

list_alt

Causes of Pituitary and Hypothalamic Disorders

Pituitary and hypothalamic disorders result from overproduction or underproduction of hormones. Providers don’t always know why this happens, but causes may include:

Pituitary Adenomas and Cysts

Tumors or cysts on or near the pituitary gland are the most common causes of these disorders.

Genetics

A gene change (mutation) may lead to gland dysfunction.

Infections

Brain infections such as meningitis can damage your glands.

Inflammation

Swelling due to autoimmune diseases or medications can harm your glands.

Injury

A brain injury or stroke can harm your pituitary or hypothalamic glands.

Nutrition Problems

Eating disorders or extreme weight loss may damage your pituitary and hypothalamic glands.

Surgery or Radiation

Neurological surgery or radiation treatment on the brain (neuroradiology) can lead to gland disorders.

troubleshoot

Diagnosing Pituitary and Hypothalamic Disorders

Our providers at UC Davis Health specialize in diagnosing pituitary and hypothalamic disorders. We first ask you about your symptoms and family history. Then we will do blood and urine tests to check your hormone levels.

We may also recommend imaging tests, such as an MRI or CT scan. Imaging allows us to see if your pituitary gland has grown or shrunk and to check for tumors.

We can also take a sample of your pituitary gland (biopsy) to check the cells for cancer. If we suspect a tumor, we may also do a visual field eye exam to look for vision loss.

Pituitary and Hypothalamic Disorders Treatments at UC Davis Health

At UC Davis Health, we offer the latest treatments to people with pituitary and hypothalamic disorders. Your provider may recommend one approach or a combination of therapies, including:

Medication

We treat some pituitary and hypothalamic disorders with medications. These medications can increase or suppress your glands’ production of hormones, depending on the disorder.

Radiation Therapy

We may use radiation therapy to shrink tumors.

Surgery

We may recommend neurological surgery to remove any tumors from your pituitary or hypothalamic glands. We often use minimally invasive surgery, depending on the size and location of the tumors.

Less than

0.2%Of pituitary gland tumors are cancerous

Source: American Society of Clinical Oncology (ASCO): Pituitary Gland Tumor: Statistics

Request an Appointment

As Sacramento's No. 1 hospital, you'll benefit from unique advantages in primary care and specialty care. This includes prevention, diagnosis and treatment options from experts in 150 specialties.

Referring Physicians

To refer a patient, you can submit an electronic referral form or call.

family_restroom

Patients

For questions and appointment information

Awards and Recognitions
PreviousNext
USNWR Best Hospital badge

Ranked among the nation’s best hospitals

A U.S. News & World Report best hospital in cancer, cardiology, heart & vascular surgery, diabetes & endocrinology, ENT, geriatrics, neurology & neurosurgery, obstetrics & gynecology, and pulmonology & lung surgery.

Learn more
US News & World Report best Children’s Hospital badge

Ranked among the nation’s best children’s hospitals

A U.S. News & World Report best children’s hospital in diabetes & endocrinology, nephrology, and orthopedics*. (*Together with Shriners Children’s)

Learn more
USNWR best regional hospital badge

Ranked Sacramento’s #1 hospital

Ranked Sacramento’s #1 hospital by U.S. News, and high-performing in COPD, colon cancer surgery, diabetes, heart attack, heart failure, hip fracture, hip replacement, kidney failure, leukemia, lymphoma & myeloma, lung cancer surgery, ovarian cancer surgery, pneumonia, prostate cancer surgery, stroke, TAVR, uterine cancer surgery, gastroenterology & GI surgery, and orthopedics.

Learn more
Magnet designation badge

The nation’s highest nursing honor

UC Davis Medical Center has received Magnet® recognition, the nation’s highest honor for nursing excellence.

Learn more
Chime acute badge

“Most Wired” for acute care

UC Davis Health has been recognized as a level 10 out of 10 in the Digital Health “Most Wired” program from the College of Healthcare Information Management Executives (CHIME). The honor recognizes excellence in using technology to improve the delivery of care.

Learn more
Chime ambulatory badge

“Most Wired” for ambulatory care

UC Davis Health has been recognized as a level 10 out of 10 in the Digital Health “Most Wired” program from the College of Healthcare Information Management Executives (CHIME). The honor recognizes excellence in using technology to improve the delivery of care.

Learn more
NCI badge

World-class cancer care

One of ~56 U.S. cancer centers designated “comprehensive” by the National Cancer Institute.

Learn more
HEI LGBTQ badge

A leader in health care equality

For the 11th consecutive year, UC Davis Medical Center has been recognized as a “Leader in LGBTQ+ Healthcare Equality.”

Learn more
See more