James Littlejohn, M.D., Ph.D. for UC Davis Health

James Littlejohn, M.D., Ph.D.

Associate Professor, Division of Clinical Anesthesiology

James Littlejohn is not currently accepting new patients. For assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).




Critical Care Medicine

Locations and Contact

Patient Support Services Building

Patient Support Services Building
4150 V St.
Sacramento, CA 95817

Get Directions

Phone: 916-734-5031

Additional Numbers

Clinic Fax


Philosophy of Care

I believe in the holistic, compassionate and open minded approach to each patient and their specific situation and disease process. I also firmly and fundamentally believe in practicing in an academic medical center and improving the quality of the future of health care in the world by being an influencial and effective teacher and mentor to future care providers.

Clinical Interests

Dr. Littlejohn has clinical interests and expertise in cardiothoracic and trauma related anesthesiology and critical care medicine; including mechanical circulatory support as well as identification and treatment of acquired coagulopathy.  

Research/Academic Interests

Dr. Littlejohn’s research interests include (formerly) infectious disease/structural biology, and currently involve preoperative coagulopathies, point-of-care viscoelastic testing (ROTEM and TEG), as well as blood conservation techniques.


General Anesthesiology

Undergraduate School

B.A., UC Berkeley, Berkeley CA 2002

Medical School

M.D., Texas A&M University College of Medicine, Bryan TX 2010


Anesthesia, New York Presbyterian-Weill Cornell Medical Center, New York NY 2010-2011


Anesthesiology, New York Presbyterian-Weill Cornell Medical Center, New York NY 2010-2014


Critical Care Medicine, University of Pennsylvania Medical Center, Philadelphia PA 2014-2015

The Marjorie Topkins Award, 2021 Teacher of the Year, Department of Anesthesiology of Weill Cornell Medicine, 2021

Choosing Wisely Champion, American Society of Clinical Pathology, for exemplary work to reduce overuse and improve the United States health care system, 2018

Chief of Staff Award, Exemplary service in critical care to the UCDMC Medical Staff, UC Davis Medical Center, 2018

Outstanding Teacher of the Year, Department of Anesthesiology and Pain Medicine, UC Davis Medical Center, 2015-16, 2017-2018, 2018

Translation Research Grant, New York Presbyterian-Weill Cornell Medical Center, 2014

Littlejohn J, Vasovic LV, Cushing MM, Barie PS. Fibrinolysis Shutdown in Severe COVID-19: Highly Prevalent but not Independently Predictive of Thrombosis or Poorer Outcomes. J Am Coll Surg. 2022 Jan 1;234(1):97-98. doi:10.1097/XCS.0000000000000007. PMID:35213468.

Vasovic LV, Littlejohn J, Alqunaibit D, Dillard A, Qiu Y, Rand S, Bronstein M, Gibson CJ, Kelly AG, Lee C, Minneman JA, Narayan M, Shou J, Smith KE, Villegas CV, Winchell RJ, Cushing MM, Barie PS. Rotational thromboelastometry in patients with acute respiratory distress syndrome owing to coronavirus disease 2019: Is there a viscoelastic fingerprint and a role for predicting thrombosis? Surgery. 2022 Apr;171(4):1092-1099. doi:10.1016/j.surg.2021.08.051. Epub 2021 Sep 9. PMID:35090739.

Trappey AF 3rd, Thompson KM, Kuppermann N, Stephenson JT, Nuno MA, Hewes HA, Meyers SR, Stanley RM, Galante JM, Nishijima DK; Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC) Collaborators of the Pediatric Emergency Care Applied Research Network (PECARN). Development of transfusion guidelines for injured children using a Modified Delphi Consensus Process. J Trauma Acute Care Surg. 2019 Oct;87(4):935-943. doi:10.1097/TA.0000000000002432. Erratum in: J Trauma Acute Care Surg. 2022 May 1;92(5):949. PMID:31299040.

Flynn BC, Shen L, Littlejohn JE, Shirak MO, Ivascu NS. Noteworthy Literature in 2018 for Cardiovascular Anesthesiologists and Intensivists. Semin Cardiothorac Vasc Anesth. 2019 Jun;23(2):156-163. doi:10.1177/1089253219842659. Epub 2019 Apr 15. PMID:30985250.

Raiten JM, Wong ZZ, Spelde A, Littlejohn JE, Augoustides JGT, Gutsche JT. Anticoagulation and Transfusion Therapy in Patients Requiring Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. 2017 Jun;31(3):1051-1059. doi:10.1053/j.jvca.2016.08.011. Epub 2016 Aug 10. PMID:27815114.

Rascoe PA, Jupiter D, Cao X, Littlejohn JE, Smythe WR. Molecular pathogenesis of malignant mesothelioma. Expert Rev Mol Med. 2012 May 24;14:e12. doi:10.1017/erm.2012.6. PMID:22622048.

Zhang L, Littlejohn JE, Cui Y, Cao X, Peddaboina C, Smythe WR. Characterization of bortezomib-adapted I-45 mesothelioma cells. Mol Cancer. 2010 May 18;9:110. doi:10.1186/1476-4598-9-110. PMID:20482802.

Cao X, Littlejohn J, Rodarte C, Zhang L, Martino B, Rascoe P, Hamid K, Jupiter D, Smythe WR. Up-regulation of Bcl-xl by hepatocyte growth factor in human mesothelioma cells involves ETS transcription factors. Am J Pathol. 2009 Nov;175(5):2207-16. doi:10.2353/ajpath.2009.090070. Epub 2009 Oct 15. PMID:19834061.