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Bethany P. Cummings, D.V.M., Ph.D.
Associate Professor
Locations and Contact
Additional Numbers
Physician Referrals
Research/Academic Interests
Dr. Cummings' research uses state-of-the-art tools and technologies to understand the molecular basis of metabolic disease. The aim is to identify and develop new therapeutics for these diseases, whose prevalence is growing at an alarming rate. To achieve these goals, her lab is studying surgical, pharmaceutical and nutritional interventions.
Division
Foregut, Metabolic and General Surgery
Center/Program Affiliation
Undergraduate School
B.S., Biology, Brandeis University, Waltham MA 2005
Medical School
D.V.M., UC Davis, Davis CA 2011
Other School
Ph.D., UC Davis, Davis CA 2009
Saikia M, Holter MM, Donahue LR, Lee IS, Zheng QC, Wise JL, Todero JE, Phuong DJ, Garibay D, Coch R, Sloop KW, Garcia-Ocana A, Danko CG, Cummings BP. GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells. JCI Insight. 2021 Feb 8;6(3):e141851. doi:10.1172/jci.insight.141851. PMID:33554958.
Allegretti JR, Kassam Z, Hurtado J, Marchesi JR, Mullish BH, Chiang A, Thompson C, Cummings BP. Fecal Microbiota Transplantation for the Treatment of Obesity: Secondary Analysis. International J of Endocrinology and Metabolism. 2021 Mar;20(1):209-211. doi:10.1007/s42000-020-00265-z.
Holter MM, Chirikjian MK, Govani VN, Cummings BP. TGR5 Signaling in Hepatic Metabolic Health. Nutrients. 2020 Aug 26;12(9):2598. doi:10.3390/nu12092598. PMID:32859104.
Holter MM, Chirikjian MK, Briere DA, Maida A, Sloop KW, Schoonjans K, Cummings BP. Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice. Nutrients. 2020 Jul 17;12(7):2124. doi:10.3390/nu12072124. PMID:32708970.
Holter MM, Garibay D, Lee SA, Saikia M, McGavigan AK, Ngyuen L, Moore ES, Daugherity E, Cohen P, Kelly K, Weiss RS, Cummings BP. Hepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy in mice. FASEB J. 2020 Jan;34(1):1846-1858. doi:10.1096/fj.201902214R. Epub 2019 Dec 10. PMID:31914635.
Garibay D, Zaborska KE, Shanahan M, Zheng Q, Kelly KM, Montrose DC, Dannenberg AJ, Miller AD, Sethupathy P, Cummings BP. TGR5 Protects Against Colitis in Mice, but Vertical Sleeve Gastrectomy Increases Colitis Severity. Obes Surg. 2019 May;29(5):1593-1601. doi:10.1007/s11695-019-03707-9. PMID:30623320.
Garibay D, Lou J, Lee SA, Zaborska KE, Weissman MH, Sloma E, Donahue L, Miller AD, White AC, Michael MD, Sloop KW, Cummings BP. β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice. Cell Rep. 2018 Apr 24;23(4):967-973. doi:10.1016/j.celrep.2018.03.120. PMID:29694904.
McGavigan AK, Henseler ZM, Garibay D, Butler SD, Jayasinghe S, Ley RE, Davisson RL, Cummings BP. Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice. Dis Model Mech. 2017 Mar 1;10(3):235-243. doi:10.1242/dmm.027474. Epub 2017 Jan 12. PMID:28093508.
Garibay D, McGavigan AK, Lee SA, Ficorilli JV, Cox AL, Michael MD, Sloop KW, Cummings BP. β-Cell Glucagon-Like Peptide-1 Receptor Contributes to Improved Glucose Tolerance After Vertical Sleeve Gastrectomy. Endocrinology. 2016 Sep;157(9):3405-9. doi:10.1210/en.2016-1302. Epub 2016 Aug 8. PMID:27501183.
McGavigan AK, Garibay D, Henseler ZM, Chen J, Bettaieb A, Haj FG, Ley RE, Chouinard ML, Cummings BP. TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut. 2017 Feb;66(2):226-234. doi:10.1136/gutjnl-2015-309871. Epub 2015 Oct 28. PMID:26511794.